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Gene Information
Gene symbol: FAP
Gene name: fibroblast activation protein, alpha
HGNC ID: 3590
Synonyms: DPPIV
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | DPP8 | 1 hits |
| 2 | DPP9 | 1 hits |
| 3 | GCG | 1 hits |
| 4 | GIP | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21510839 | Dipeptidyl peptidase-IV (DPP-IV), a serine protease that specifically cleaves the N-terminal dipeptide with a preference for L-proline or L-alanine at the penultimate position, is involved in the degradation of incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). |
| 2 | 21510839 | Consequently, small-molecule DPP-IV inhibitors that could extend the duration of action of GLP-1 and prolong its beneficial effects have been investigated as potential therapeutics for type 2 diabetes. |
| 3 | 21510839 | Because inhibition of DPP8 and/or DPP9 has been shown to cause severe toxicity in preclinical species, high selectivity is an important criterion in selecting DPP-IV inhibitors for clinical development. |