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Gene Information
Gene symbol: FLT1
Gene name: fms-related tyrosine kinase 1
HGNC ID: 3763
Synonyms: VEGFR1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | CTGF | 1 hits |
| 3 | KDR | 1 hits |
| 4 | MAPK1 | 1 hits |
| 5 | MAPK10 | 1 hits |
| 6 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10977134 | VEGF also increases the expression of the receptors, KDR and Flt-1, and activates the p44/42 MAP kinase pathway. |
| 2 | 11018037 | VEGF activated the tyrosine receptor phosphorylation of KDR and Flt1 and increased the binding of phosphatidylinositol 3-kinase (PI3-kinase) p85 subunit to KDR and Flt1, both of which could mediate CTGF gene induction. |
| 3 | 11018037 | These data suggest that VEGF can increase CTGF gene expression in bovine retinal capillary cells via KDR or Flt receptors and the activation of PI3-kinase-Akt pathway independently of PKC or Ras-ERK pathway, possibly inducing the fibrosis observed in retinal neovascular diseases. |
| 4 | 17823371 | In the absence of ischemia, DM mice had increased VEGF (NC versus DM: 26.6+/-2.6 versus 53.5+/-8.8 pg/mg protein; P<0.05), decreased soluble and membrane-bound VEGFR-1 (NC versus DM: 1.44+/-0.30 versus 0.85+/-0.08 and 1.03+/-0.10 versus 0.72+/-0.10, respectively; P<0.05), decreased phospho-AKT/AKT and phospho-endothelial NO synthase/endothelial NO synthase (NC versus DM: 0.76+/-0.2 versus 0.38+/-0.1 and 0.36+/-0.06 versus 0.25+/-0.04, respectively; P<0.05), and no change in VEGFR-2. |
| 5 | 20674013 | In this study, we analised the expression of VEGF and its receptors VEGFR-1 (Flt-1) and VEGFR-2 (KDR) in placentas from mildly hyperglycemic women. |
| 6 | 12000720 | When endogenous VEGF bioactivity was inhibited with a soluble Flt-1/Fc chimera, retinal Akt kinase activity was significantly reduced in vivo. |