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Gene Information
Gene symbol: FOXO6
Gene name: forkhead box O6
HGNC ID: 24814
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21940782 | FoxO6 integrates insulin signaling to hepatic gluconeogenesis. |
| 2 | 21940782 | Insulin inhibits FoxO6 activity via a distinct mechanism by inducing its phosphorylation and disabling its transcriptional activity, without altering its subcellular distribution in hepatocytes. |
| 3 | 21940782 | Our data uncover a FoxO6-dependent pathway by which the liver orchestrates insulin regulation of gluconeogenesis, providing the proof-of-concept that selective FoxO6 inhibition is beneficial for curbing excessive hepatic glucose production and improving glycemic control in diabetes. |