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Gene Information
Gene symbol: FURIN
Gene name: furin (paired basic amino acid cleaving enzyme)
HGNC ID: 8568
Synonyms: SPC1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ENPP2 | 1 hits |
| 2 | INS | 1 hits |
| 3 | PLA2G4A | 1 hits |
| 4 | SERPINE1 | 1 hits |
| 5 | TGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10927633 | Primary human fibroblasts, myoblasts and stabilized cell lines (HepG2 and NIH3T3) were transduced either with a retroviral vector coding for wild-type proinsulin or for a genetically mutated one, carrying cleavage sites sensitive to furin. |
| 2 | 11177550 | We constructed LhI*TFSN virus to encode a glucose-regulatable transforming growth factor alpha promoter controlling furin expression with a viral LTR promoter driving constitutive expression of furin-cleavable human proinsulin. |
| 3 | 17920636 | These cell lines have been developed by stably and constitutively expressing human proinsulin with a furin-cleavable site, whereas expression of furin is regulated by glucose concentration. |
| 4 | 21406565 | Here, we demonstrate that the serine protease inhibitor plasminogen activator inhibitor 1 (PAI-1) forms an SDS-stable complex with the PC furin, which leads to the inhibition of the intra-Golgi activity of furin. |
| 5 | 21406565 | It is known that elevated PAI-1 plasma levels are correlated with the occurrence of the metabolic syndrome and type 2 diabetes, and we show that PAI-1 reduces the furin-dependent maturation and activity of the insulin receptor and ADAM17: two proteins involved in the onset of these metabolic disorders. |
| 6 | 21406565 | In addition to demonstrating that PAI-1 is an intracellular inhibitor of furin, this study also provides arguments in favor of an active role for PAI-1 in the development of metabolic disorders. |
| 7 | 17208043 | Transfection in Cos-7 cells of site-directed deleted ATX shows that the furin recognition site is not required for secretion or lysophospholipase D activity of ATX. |