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Gene Information
Gene symbol: G6PC
Gene name: glucose-6-phosphatase, catalytic subunit
HGNC ID: 4056
Synonyms: GSD1a
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GCK | 1 hits |
| 2 | GCKR | 1 hits |
| 3 | IL6 | 1 hits |
| 4 | INS | 1 hits |
| 5 | STAT3 | 1 hits |
| 6 | TCF7L2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18316359 | Our aim was to evaluate the relationship between insulin resistance and the expression and regulation of forkhead box-containing protein O subfamily-1 (FOXO1), a transcription factor that mediates the effect of insulin on the gluconeogenic genes PEPCK and glucose-6-phosphatase catalytic subunit (G6PC). |
| 2 | 20484139 | The reduced hepatic glucose output coincided with decreased expression of the gluconeogenic genes G6pc and Pck1 and enhanced hepatic STAT3 phosphorylation and PI3K/Akt signaling in the fasted state. |
| 3 | 20484139 | The increased insulin and IL-6 signaling resulted in enhanced suppression of G6pc and Pck1 mRNA. |
| 4 | 21901280 | Silencing of TCF7L2 induced a marked increase in basal HGP, which was accompanied by significant increases in the expression of the gluconeogenic genes Fbp1, Pck1 and G6pc. |
| 5 | 22013014 | RESULTS Accumulation of phosphorylated intermediates in hepatocytes incubated at elevated glucose induced rapid and inverse changes in Gck (repression) and Gckr (induction) mRNA concomitantly with induction of G6pc, but had slower effects on the Gckr-to-Gck protein ratio. |