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Gene Information
Gene symbol: G6PD
Gene name: glucose-6-phosphate dehydrogenase
HGNC ID: 4057
Synonyms: G6PD1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ALB | 1 hits |
| 2 | CNBP | 1 hits |
| 3 | DUOX1 | 1 hits |
| 4 | INS | 1 hits |
| 5 | NFKB1 | 1 hits |
| 6 | NOX5 | 1 hits |
| 7 | PI3 | 1 hits |
| 8 | SRC | 1 hits |
| 9 | SREBF1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7476335 | Intestinal activities of the redox enzymes, GSH peroxidase, GSSG reductase, and glucose-6-phosphate dehydrogenase (G6PD), were significantly decreased by 17 hours' insulin treatment, whereas only G6PD was decreased by fasting. |
| 2 | 7476335 | Insulin treatment for 7 consecutive days increased hepatic G6PD activity by fourfold but was without effect on intestinal G6PD, suggesting tissue specificity in insulin regulation of G6PD. |
| 3 | 17065329 | Adipogenic G6PD overexpression promotes the expression of pro-oxidative enzymes, including inducible nitric oxide synthase and NADPH oxidase, and the activation of nuclear factor-kappaB (NF-kappaB) signaling, which eventually leads to the dysregulation of adipocytokines and inflammatory signals. |
| 4 | 19062325 | The isoforms of the transcription factor sterol regulatory element binding protein 1 (SREBP-1) are known to stimulate G6PD gene expression, and some polymorphisms in the SREBP-1 gene (SREBF-1) have been described only in Africans. |
| 5 | 19230846 | Inhibition of PI3 kinase and Src kinases decreased (p < 0.05) G6PD activity in the fa/fa but not in the lean rat liver, suggesting that G6PD activity is regulated by PI3/Src kinase signaling pathways. |
| 6 | 19230846 | G6PD-derived NADPH increased (p < 0.05) superoxide anion levels by 70-90% in fa/fa vs lean rat liver, which was inhibited by the NADPH oxidase inhibitor gp91(ds-tat) (50 microM) and G6PD inhibitors 6-aminonicotinamide (1 mM) and dehydroepiandrosterone (100 microM), therefore indicating that elevated G6PD activity may be responsible for mediating superoxide generation. |
| 7 | 19805580 | G6PD-deficient mice had increased protein kinase C activity, increased nuclear factor-kappaB activity, and increased urinary albumin levels, all of which is similar to changes seen in diabetic mice. |
| 8 | 21147013 | Conversely, G6PD deficiency can promote oxidative stress and impairment of insulin secretion by beta cells. |
| 9 | 21248143 | In INS-1 cells, G6PD overexpression augmented ROS accumulation associated with increased expression of prooxidative enzymes, such as inducible nitric oxide synthase and reduced nicotinamide adenine dinucleotide phosphate oxidase. |
| 10 | 20032314 | Inhibition of G6PD with siRNA led to increased ROS and apoptosis, decreased proliferation, and impaired insulin secretion. |