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Gene Information
Gene symbol: GAB2
Gene name: GRB2-associated binding protein 2
HGNC ID: 14458
Synonyms: KIAA0571
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CBLB | 1 hits |
| 2 | EGFR | 1 hits |
| 3 | INS | 1 hits |
| 4 | PIK3R1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12138086 | EGF increased the tyrosine phosphorylation of several proteins (the EGF receptor, insulin receptor substrate (IRS)-1, IRS-2, and Grb2-associated binder 1), whereas Shc and Gab2 were only weakly and inconsistently phosphorylated. p85, the regulatory subunit of phosphatidylinositol 3-kinase (PI 3-kinase), was also found to associate with all of these docking molecules, showing that EGF activated PI 3-kinase pools that were additional to those of insulin. |
| 2 | 16002993 | FcepsilonRI-mediated tyrosine phosphorylation of Syk, Gab2, and phospholipase C-gamma1, and activation of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase (MAP kinase), and inhibitor of nuclear factor kappaB kinase (IKK), and generation of Rac1 are unaffected in cells overexpressing the truncated Cbl-b in the lipid raft. |
| 3 | 20004975 | Effect of insulin on FcepsilonRI signaling pathways was marked by enhanced phosphorylation of Lyn, Fyn, Gab2 and Akt. |