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Gene Information
Gene symbol: GADD45B
Gene name: growth arrest and DNA-damage-inducible, beta
HGNC ID: 4096
Synonyms: GADD45BETA, DKFZP566B133
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | DDIT3 | 1 hits |
| 2 | GADD45A | 1 hits |
| 3 | IL1B | 1 hits |
| 4 | INS | 1 hits |
| 5 | MAPK1 | 1 hits |
| 6 | MAPK8 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16283526 | Ikkbeta deficiency prevented the induction of gadd45beta and gadd45gamma by arsenic, whereas the induction of gadd45alpha and gadd153 was appreciably enhanced in Ikkbeta-/- cells. |
| 2 | 16528573 | The aim of this study was to investigate if Gadd45b prevents IL-1beta-induced beta cell MAPK signalling and apoptosis. |
| 3 | 16528573 | The effects of Gadd45b expression on signalling by JNK, ERK and p38 were assessed by Western blotting and kinase assays. |
| 4 | 16528573 | In INS-1E and beta-TC3 cells, expression of Gadd45b inhibited IL-1beta-induced activation of JNK and ERK, but augmented IL-1beta-mediated p38 activity. |
| 5 | 16528573 | IL-1beta-induced nitric oxide production and decreases in insulin content and secretion were reduced by GADD45beta. |
| 6 | 16528573 | Although IL-1beta stimulated the time-dependent induction of endogenous Gadd45b in INS-1E cells and rat islets, expression levels were lower in these cells than in IL-1beta-exposed NIH-3T3 and 3DO T cells. |
| 7 | 16528573 | Inadequate induction of Gadd45b, which encodes a novel beta cell JNK and ERK inhibitor, may in part explain the pro-apoptotic response of beta cells to IL-1beta. |