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Gene Information

Gene symbol: GCKR

Gene name: glucokinase (hexokinase 4) regulator

HGNC ID: 4196

Related Genes

#	Gene Symbol	Number of hits
1	BCHE	1 hits
2	G6PC	1 hits
3	GCK	1 hits

Related Sentences

#	PMID	Sentence
1	10622744	However, the fractional decrease in nuclear GKRP is smaller than for glucokinase and is determined by the metabolic state and not by the distribution of glucokinase.
2	15983194	Hepatic glucokinase is regulated by a 68-kDa regulatory protein (GKRP) that is both an inhibitor and nuclear receptor for glucokinase.
3	15983194	Thus, it acts in a complementary mechanism to GKRP, which also regulates glucokinase protein expression and compartmentation.
4	19643913	Glucokinase (GCK) regulates glucose storage and disposal in the liver where its activity is regulated by glucokinase regulatory protein (GKRP; gene name GCKR).
5	19643913	Assays matched for GKRP activity demonstrated no difference in dose-dependent inhibition of GCK activity or F1P-mediated regulation.
6	20352598	In conclusion, long-term genetic glucokinase activation by the GKRP polymorphisms was not associated with an increased cardiovascular risk in the study population.
7	21490074	Hepatic GCK activity is regulated on the level of GCK mRNA expression and by the inhibitory glucokinase regulatory protein.
8	21862451	In particular, SNPs within FTO and GCKR were associated with BCHE activity, but their effects were partly mediated by body mass index and triglycerides, respectively.
9	21921030	Disruption of the glucokinase regulatory protein-binding site (GCK(K140E)), but not the ATP binding cassette (GCK(P417R)), prevented inhibition of enzyme activity by glucokinase regulatory protein and corresponded with reduced responsiveness to the GKA drug.
10	22013014	RESULTS Accumulation of phosphorylated intermediates in hepatocytes incubated at elevated glucose induced rapid and inverse changes in Gck (repression) and Gckr (induction) mRNA concomitantly with induction of G6pc, but had slower effects on the Gckr-to-Gck protein ratio.