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Gene Information
Gene symbol: GCLC
Gene name: glutamate-cysteine ligase, catalytic subunit
HGNC ID: 4311
Synonyms: GCS
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | CAT | 1 hits |
| 3 | GCA | 1 hits |
| 4 | INS | 1 hits |
| 5 | INSR | 1 hits |
| 6 | PIK3CA | 1 hits |
| 7 | RORC | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7651354 | Specifically, the addition of insulin or hydrocortisone to culture media or the lowering of the initial plating cell density increased cell GSH by increasing the activity of GCS. |
| 2 | 17109620 | Insulin stimulated glutamate-L-cysteine ligase (GCL) activity by activation of phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR signaling, increased serine phosphorylation and nuclear translocation of nuclear NF-E2-related factor 2 (Nrf2), and upregulation of Nrf2-dependent GCL-catalytic (GCLc) subunit expression. |
| 3 | 17109620 | Inhibitors of insulin receptor tyrosine kinase, PI3K, Akt and mTOR abrogated insulin-induced Nrf2-mediated GCLc expression, redox balance, and IHEC survival. |
| 4 | 19463904 | Inhibitors of PI3K (LY294002), Akt (Akt-I), and mTOR (rapamycin) reduced the GLP-1-induced GCLc upregulation and its protection against MG-induced PC12 apoptosis. |
| 5 | 21217061 | High-glucose-induced upregulation of NQO1, GCLC, and HMOX1 was also prevented by pretreatment with polyethylene glycol (PEG)-catalase or N-acetylcysteine, whereas administration of H(2)O(2) mimicked the effect of high glucose. |