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Gene Information
Gene symbol: GDF15
Gene name: growth differentiation factor 15
HGNC ID: 30142
Synonyms: PLAB, MIC-1, PDF, MIC1, NAG-1, PTGFB
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FGF2 | 1 hits |
| 2 | LEP | 1 hits |
| 3 | TFRC | 1 hits |
| 4 | TNNT2 | 1 hits |
| 5 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17721544 | In comparison, individuals with beta-thalassemia syndromes had elevated GDF15 serum levels (mean 66,000 +/- 9,600 pg/ml; range 4,800-248,000 pg/ml; P < 0.05) that were positively correlated with the levels of soluble transferrin receptor, erythropoietin and ferritin. |
| 2 | 19759273 | Chronic high-glucose-based PDF exposure resulted in increased vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) expression, accumulation of advanced glycation end-products (AGEs), and up-regulation of the receptor for AGE (RAGE), which were ameliorated in the icodextrin-based PDF group. |
| 3 | 20855664 | In a comprehensive multiple-variable Cox regression model that included clinical prognostic variables, B-type natriuretic peptide, high-sensitivity C-reactive protein, and high-sensitivity troponin T, GDF-15 remained independently associated with mortality (hazard ratio, 1.007; 95% confidence interval, 1.001 to 1.014; P=0.02) but not first morbid event. |
| 4 | 20855664 | Increases in GDF-15 over 12 months were independently associated with the risks of future mortality and first morbid event also after adjustment for clinical prognostic variables, B-type natriuretic peptide, high-sensitivity C-reactive protein, and high-sensitivity troponin T and their changes. |
| 5 | 21164037 | Roux-en-Y gastric bypass led to a significant reduction in weight, leptin, insulin, and insulin resistance, but further increased GDF-15 concentrations (P < 0.001). |