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Gene Information
Gene symbol: GDNF
Gene name: glial cell derived neurotrophic factor
HGNC ID: 4232
Synonyms: ATF1, ATF2, HFB1-GDNF
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | GSK3B | 1 hits |
| 3 | INS | 1 hits |
| 4 | PAX6 | 1 hits |
| 5 | PDX1 | 1 hits |
| 6 | RARA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17470563 | Here, we demonstrate that retinoic acid receptor (RAR)alpha stimulants preferentially act on glial cells rather than endothelial cells, resulting in the enhanced expression of glial cell line-derived neurotrophic factor (GDNF) through recruitment of the RARalpha-driven trans-acting coactivator to the 5'-flanking region of the gene promoter. |
| 2 | 18241861 | Exposure of beta-cells to GDNF also resulted in phosphorylation of Akt and GSK3beta. |
| 3 | 18241861 | Transgenic mice that overexpress GDNF in glia exhibit increased beta-cell mass, proliferation, and insulin content. |
| 4 | 20448145 | Transgenic expression of GDNF in mouse pancreata was associated with increased numbers of Ngn3-expressing pancreatic cells and higher beta-cell mass at embryonic day 18 (E18), as well as higher beta-cell proliferation and Pdx1 expression in beta-cells at E18 and postnatal day 1. |
| 5 | 20448145 | In the HIT-T15 beta-cell line, GDNF enhanced the expression of Pax6. |
| 6 | 20448145 | Chromatin immunoprecipitation studies using the HIT-T15 beta-cell line demonstrated that GDNF can influence Pdx1 gene expression by enhancing the binding of Sox9 and neuroD1/beta(2) to the Pdx1 promoter. |
| 7 | 21869742 | Human islets were cultured in medium supplemented with or without GDNF (100 ng/mL) and in vitro islet survival and function assessed by analyzing ?-cell apoptosis and glucose stimulated insulin release. |