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Gene Information
Gene symbol: GFPT1
Gene name: glutamine--fructose-6-phosphate transaminase 1
HGNC ID: 4241
Synonyms: GFAT, GFA, GFAT1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCND1 | 1 hits |
| 2 | LAMC1 | 1 hits |
| 3 | NFKB1 | 1 hits |
| 4 | OGT | 1 hits |
| 5 | PLCG1 | 1 hits |
| 6 | POMGNT1 | 1 hits |
| 7 | TGFB1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 1460020 | Recombinant GFAT activity was inhibited 51% by UDP-GlcNAc whereas bacterial GFAT activity was insensitive to inhibition by UDP-GlcNAc. |
| 2 | 9421478 | Inhibition of GFAT by the substrate analogue azaserine or by inhibition of GFAT protein synthesis with antisense oligonucleotide prevented the high glucose-induced increase in cellular glucosamine metabolites and TGF-beta1 expression and bioactivity and subsequent effects on mesangial cell proliferation and matrix production. |
| 3 | 9421478 | Overall, our study indicates that the flux of glucose metabolism through the GFAT catalyzed hexosamine biosynthetic pathway is involved in the glucose-induced mesangial production of TGF-beta leading to increased matrix production. |
| 4 | 11916938 | Overexpression of glutamine:fructose-6-phosphate amidotransferase (GFAT), the rate-limiting enzyme for flux through the hexosamine pathway, led to a 2.2-fold increase in NF-kappaB enhancer activity; the combination of GFAT overexpression and high glucose increased activity 2.8-fold, and these increases were prevented by 40 micromol/l O-diazoacetyl-L-serine (azaserine) or 6-diazo-5-oxonorleucine. |
| 5 | 11916938 | High glucose, glucosamine, and GFAT overexpression increased binding of MC nuclear proteins to NF-kappaB consensus sequences. |
| 6 | 11916938 | Inactivation of the two NF-kappaB sites in the VCAM-1 promoter abolished its response to high glucose, glucosamine, and GFAT overexpression. |
| 7 | 16339923 | UDP-GlcNAc regulates flux through HBP by regulating GFAT activity and is the obligatory substrate of O-GlcNAc transferase. |
| 8 | 16892452 | Azaserine, an inhibitor of glutamine:fruc-6-PO(4) amidotransferase (GFAT) in the HBP, blocks the HG-induced expression of laminin gamma1 and cyclin D1, but not GlcN's effect because it exerts its metabolic function distal to GFAT. |