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Gene Information
Gene symbol: GJA1
Gene name: gap junction protein, alpha 1, 43kDa
HGNC ID: 4274
Synonyms: CX43, ODD, ODOD, SDTY3
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD33 | 1 hits |
| 2 | CLEC11A | 1 hits |
| 3 | CYBA | 1 hits |
| 4 | GAPDH | 1 hits |
| 5 | GJA8 | 1 hits |
| 6 | GJB1 | 1 hits |
| 7 | GJB2 | 1 hits |
| 8 | GJC1 | 1 hits |
| 9 | GJD2 | 1 hits |
| 10 | MMP2 | 1 hits |
| 11 | NAT13 | 1 hits |
| 12 | NCF2 | 1 hits |
| 13 | NOX5 | 1 hits |
| 14 | PRKCG | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17102126 | Immunohistochemistry showed that Cx50 expression seemed to be the predominant form of Cx expressed in human chromaffin cells, whereas Cx43 immunoreactivity was the most prominent form found in the adrenal cortex. |
| 2 | 17612968 | Cellular insulin-like growth factor-1 (IGF-1), PKC-gamma phosphorylation of Cx43 on Ser368, and activation of phospholipase C-gamma 1 (PLC-gamma 1), extracellular signal-regulated kinase (ERK1/2), and caspase-3 were determined by Western blotting. |
| 3 | 17612968 | The level of PKC-gamma -catalyzed phosphorylation of Cx43 on Ser368 and resulting inhibition of lens gap junction dye transfer activity was increased in the VHG diabetic lenses. |
| 4 | 17612968 | These were correlated with activation of PKC-gamma, phosphorylation of Cx43 on Ser368, and inhibition of dye transfer. |
| 5 | 17632690 | Expression levels of mRNA for Gja5 (Cx40) and Gja1 (Cx43) were moderately increased and for Gja7 (Cx45) was significantly increased in SAN from diabetic heart compared to controls. |
| 6 | 17717278 | Cx43 is normally downregulated and Cx26 upregulated in keratinocytes at the edge of the wound as they adopt a migratory phenotype. |
| 7 | 20609064 | These findings were accompanied by downregulated Cx43 and Cx40, and upregulated PKCepsilon and NADPH oxidase subunits p22(phox)/p47(phox)/p67(phox) in the thoracic aorta. |
| 8 | 20609064 | NaHS shows promise in relieving diabetic vascular abnormality by upregulating junctional connexin Cx40 and Cx43, via normalizing NADPH oxidase and PKCepsilon in the vasculature. |
| 9 | 21267711 | With a single injection of streptozotocin 65 mg/kg, ip in rats, early diabetic nephropathy was produced and revealed as an increased microalbuminuria, elevated creatinine and urea in serum, associated with upregulation of mRNA and protein of NADPH oxidase p22phox, p47phox, and p67phox and ET(A), upregulated PKR-like eukaryotic initiation factor 2? kinase (PERK), and downregulated Cx43 in the renal tissue. |
| 10 | 21345984 | High glucose increased MMP2 and decreased connexin 43 in the mitochondria of retinal endothelial cells. |
| 11 | 21527868 | Specifically, we found that the native Cx36 does not alter islet size or insulin content, whereas the Cx43 isoform increases both parameters, and Cx32 has a similar effect only when combined with GH. |
| 12 | 21567444 | Growth in high glucose did not alter relative Cx26 level, whereas Cx30 and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) were reduced by ?30%, and Cx43 increased ?1.9-fold. |