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Gene Information
Gene symbol: GPBAR1
Gene name: G protein-coupled bile acid receptor 1
HGNC ID: 19680
Synonyms: BG37, GPCR, TGR5, M-BAR, GPCR19, GPR131, MGC40597
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | AKT1 | 1 hits |
| 3 | CHRNA9 | 1 hits |
| 4 | DTL | 1 hits |
| 5 | ECD | 1 hits |
| 6 | GCG | 1 hits |
| 7 | INS | 1 hits |
| 8 | IRS1 | 1 hits |
| 9 | IRS2 | 1 hits |
| 10 | NR1H4 | 1 hits |
| 11 | PCSK1 | 1 hits |
| 12 | PIK3CA | 1 hits |
| 13 | PRKAA1 | 1 hits |
| 14 | PRKAA2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 14529486 | GLP-1 binds with high affinity to G protein-coupled receptors (GPCRs) located on pancreatic beta-cells, and it exerts insulinotropic actions that include the stimulation of insulin gene transcription, insulin biosynthesis, and insulin secretion. |
| 2 | 17465724 | Several GPCRs are involved in metabolic regulation and glucose homeostasis such as GLP-1 receptor, glucagon receptor, adiponectin receptor and so on. |
| 3 | 18606183 | Recently some GPCRs have been shown to mediate part of their effects through activation of AMP-activated protein kinase (AMPK), a sensor of whole body energy status that plays a pivotal role in whole body energy balance by integrating signals in the periphery and central nervous system. |
| 4 | 18838178 | Several recent disulfide cross-linking studies using the M(3) muscarinic acetylcholine receptor as a model system have led to novel insights into the conformational changes associated with the activation of this prototypical class I GPCR. |
| 5 | 20424139 | It has been shown that TGR5 is expressed in enteroendocrine L cells, which secrete the potent glucose-lowering incretin hormone glucagon-like peptide-1 (GLP-1). |
| 6 | 20631053 | In line with its dual activity, INT-767 induces FXR-dependent lipid uptake by adipocytes, with the beneficial effect of shuttling lipids from central hepatic to peripheral fat storage, and promotes TGR5-dependent glucagon-like peptide-1 secretion by enteroendocrine cells, a validated target in the treatment of type 2 diabetes. |
| 7 | 20388847 | Recent results show that metformin-induced activation of AMPK disrupts crosstalk between insulin/IGF-1 receptor and GPCR signaling in pancreatic cancer cells and inhibits the growth of these cells in xenograft models. |
| 8 | 20849951 | Together, these novel findings reveal an important functional role for ?-arrestin-1 in the regulation of insulin secretion and ?-cell survival by GPCRs. |
| 9 | 15671479 | Because activation of PKB can require insulin receptor substrate proteins (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase (PI3K), it is of interest to determine whether the activity of Foxo1 is also regulated by heterotrimeric G protein-coupled receptors (GPCRs) with IRS-1 or -2, PI3K, or PKB signaling potential. |
| 10 | 15671479 | Indeed, studies of beta cells have demonstrated that activation of a GPCR for the blood glucose-lowering hormone GLP-1 leads to major alterations of IRS-2, PI3K, and PKB activity. |
| 11 | 21754919 | The discovery of TGR5 expression in brown adipocyte tissues (BATs) and the recent demonstration of BAT in adult human body suggest a potential approach to combat obesity by targeting TGR5 to increase thermogenesis. |
| 12 | 21795304 | Incubation of these cells with an agonist of TGR5 increased PC1 promoter activity and GLP-1 secretion suggesting that this is a mechanism for switching processing to GLP-1 in the pancreas. |
| 13 | 21722971 | Recently, the first crystal structure of a RAMP ECD in complex with a secretin family GPCR was solved, revealing the elegant mechanism governing receptor selectivity of small molecule antagonists of the calcitonin gene-related peptide (CGRP) receptor. |