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Gene Information
Gene symbol: GPR39
Gene name: G protein-coupled receptor 39
HGNC ID: 4496
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | HNF1A | 1 hits |
| 2 | INS | 1 hits |
| 3 | PDX1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19213833 | Islet architecture was normal in the Gpr39 null mice, but expression of Pdx-1 and Hnf-1alpha was reduced. |
| 2 | 19213841 | When fed either a low-fat/high-sucrose or high-fat/high-sucrose diet, GPR39(-/-) mice had increased fed glucose levels and showed decreased serum insulin levels during an oral glucose tolerance test in the face of unchanged insulin tolerance. |
| 3 | 19213841 | Pancreas morphology and glucose-stimulated insulin secretion in isolated islets from wild-type and GPR39(-/-) mice were comparable, suggesting that GPR39 is not required for pancreas development or ex vivo insulin secretion. |
| 4 | 19213841 | Taken together, our data indicate that GPR39 is required for the increased insulin secretion in vivo under conditions of increased demand, i.e. on development of age-dependent and diet-induced insulin resistance. |