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Gene Information
Gene symbol: GRB10
Gene name: growth factor receptor-bound protein 10
HGNC ID: 4564
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GIGYF1 | 1 hits |
| 2 | GIGYF2 | 1 hits |
| 3 | HGS | 1 hits |
| 4 | IGF1 | 1 hits |
| 5 | INS | 1 hits |
| 6 | INSR | 1 hits |
| 7 | SP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8621530 | The interaction was specific for the insulin receptor and the insulin-like growth factor-1 receptor, and it required a catalytically active receptor kinase domain and an intact Grb10 SH2 domain. |
| 2 | 8621530 | Glutathione S-transferase fusion proteins containing the Grb10 SH2 domain associated in an insulin-dependent manner with insulin receptors from cell lysates and with purified insulin receptors. |
| 3 | 8621530 | The Grb10 SH2 domain did not bind to an insulin receptor lacking 43 amino acids at the carboxyl terminus, and it exhibited highest affinity for a phosphopeptide containing Tyr(P)-1322. |
| 4 | 9062339 | Hormone-activated insulin receptors in R-IR cells coprecipitated with three species, all recognized as Grb10 isoforms by specific Grb10 antibody. |
| 5 | 9062339 | In conclusion, Grb10 interacts preferentially with insulin vs. |
| 6 | 11181517 | IRBP binding to region V was competed by VmSp1, but not by VmAT, indicating specific interactions with the AT-rich sequence; insulin response elements from other genes also failed to compete. |
| 7 | 11181517 | IRBP responded to as little as 10(-10) M insulin, indicating physiological relevance. |
| 8 | 11181517 | As most insulin-responsive genes do not exhibit insulin-responsive nuclear factor binding, further studies of IRBP may also contribute to understanding of the mechanism of insulin action on gene transcription. |
| 9 | 11457835 | Since region V contains both an Sp1 site and an AT-rich element that recognizes an insulin-responsive binding protein (IRBP), we tested the hypothesis that Sp1 interactions are facilitated by an IRBP. |
| 10 | 11457835 | These findings indicate that the presence of the AT-rich element is essential for the actions of Sp1 in vitro and in vivo, and the combination of both spacing requirements and insulin responsiveness suggests that IRBP may interact directly with Sp1. |
| 11 | 12771153 | Because Grb10 has the structure of an adapter protein, the objective of this study was to determine whether Grb10 links other proteins to IGF-I receptors and thus modulates IGF-I signaling. |
| 12 | 12771153 | Mutation analysis indicates that a 17-amino acid sequence in GIGYF1 and GIGYF2, homologous to the GYF domain described previously, binds to tandem proline-rich regions in the N terminus of Grb10. |
| 13 | 12771153 | In IGF-I receptor-expressing R+ fibroblasts, there is detectable binding of a Myc-tagged fragment of GIGYF1 to Grb10 in the basal state. |
| 14 | 12771153 | At later time points, GIGYF1 dissociates, but Grb10 remains linked to IGF-I receptors. |
| 15 | 12771153 | Overexpression of the Grb10 binding fragment of GIGYF1 in R+ cells results in a significant increase in IGF-I-stimulated receptor tyrosine phosphorylation. |
| 16 | 17445799 | Finally, we demonstrate that Hrs inhibits Nedd4-mediated VEGF-R2 degradation and acts additively with Grb10. |
| 17 | 19789144 | The GRB10 protein binds to insulin and insulin-like growth factor receptors and acts as a negative regulatory protein. |