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Gene Information
Gene symbol: GRN
Gene name: granulin
HGNC ID: 4601
Synonyms: PCDGF, PGRN, CLN11
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | IL8 | 1 hits |
| 3 | LEP | 1 hits |
| 4 | SLPI | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21085476 | Chemerin, progranulin, fetuin-A, and RBP4, IL-6, adiponectin and leptin serum concentrations were differentially regulated among the four investigated groups but only circulating chemerin was significantly different in patients with IGT compared to those with IFG. |
| 2 | 12928786 | It regulates inflammation through a tripartite loop with secretory leukocyte protease inhibitor (SLPI) which protects pgrn from proteolysis, and elastase, which digests it to smaller peptides. |
| 3 | 12928786 | Intact pgrn is anti-inflammatory through the inhibition of some of the actions of tumor necrosis factor, while the proteolytic peptides may stimulate the production of proinflammatory cytokines such as interleukin 8. |