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Gene Information
Gene symbol: GRPR
Gene name: gastrin-releasing peptide receptor
HGNC ID: 4609
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GRP | 1 hits |
| 2 | NMB | 1 hits |
| 3 | NMBR | 1 hits |
| 4 | PLCG1 | 1 hits |
| 5 | PRKCA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8380344 | Both subtypes occur widely in GI tract and the CNS; however, in contrast to the GRP-R subtype little is known about the ligand-receptor interactions for the NMB-R. |
| 2 | 8380344 | At 37 degrees C binding of 125I-[D-Tyr0]NMB to NMB-R or 125I-[Tyr4]Bn to GRP-R was maximal by 5-15 min and decreased to 60-70% after 60 min. |
| 3 | 7935330 | Recent results for truncated and mutated gastrin-releasing peptide (GRP) receptors (GRP-R), as well as muscarinic cholinergic receptors, suggest that activation of protein kinase C may be needed for full receptor internalization. |
| 4 | 7935330 | The wild-type GRP-R exposed to bombesin increased [3H]inositol phosphates (a measure of PLC activation) approximately 4-fold, with an EC50 of 5.1 +/- 2.2 nM. |
| 5 | 7562561 | [DPhe12]Bn analogs; des Met14 amides, esters and alkylamides; psi 13-14 Bn pseudopeptides; and D-amino acid-substituted analogs of substance P (SP) or SP(4-11) were all synthesized and each functioned as a GRP receptor antagonist. |
| 6 | 7562561 | These results demonstrate that none of the known strategies used to prepare peptide GRP receptor antagonists are successful at the NMB receptor, suggesting that a different strategy will be needed for this peptide, such as the formation of somatostatin octapeptide or D-amino acid-substituted substance P analogs. |