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Gene Information
Gene symbol: GSK3A
Gene name: glycogen synthase kinase 3 alpha
HGNC ID: 4616
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GCG | 1 hits |
| 2 | GSK3B | 1 hits |
| 3 | INS | 1 hits |
| 4 | MAPKAP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11978789 | GLP-2 inhibited activation of glycogen synthase kinase-3 (GSK-3) through phosphorylation at Ser(21) in GSK-3alpha and at Ser(9) in GSK-3beta in a PI3K-independent, PKA-dependent manner. |
| 2 | 16176184 | Insulin inhibits GSK3 by promoting phosphorylation of a serine residue (Ser-21 in GSK3alpha, Ser-9 in GSK3beta), thereby relieving GSK3 inhibition of glycogen synthesis in muscle. |
| 3 | 20383279 | The inhibitory effect of nitration on Akt activity was confirmed by the ability of SIN-1 to completely block GSK3alpha phosphorylation in vitro. |
| 4 | 15194499 | In myotubes established from type 2 diabetic and healthy control subjects we determined GS activity ratio, protein expression, and activity of GSK-3alpha and beta under basal and insulin-stimulated conditions when precultured in increasing insulin concentrations. |
| 5 | 15194499 | In myotubes precultured at low insulin concentrations acute insulin stimulation increased GS activity more in control than in diabetic subjects, whereas the corresponding GSK-3alpha but not GSK-3beta activity was significantly reduced by acute insulin treatment in both groups. |
| 6 | 18694957 | Mice engineered to lack GSK-3beta die in late embryogenesis from liver apoptosis, whereas mice engineered to lack GSK-3alpha are viable and exhibit improved insulin sensitivity and hepatic glucose homeostasis. |