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Gene Information
Gene symbol: GZMB
Gene name: granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HGNC ID: 4709
Synonyms: CCPI, CGL-1, CSP-B, CGL1, CTSGL1, HLP, SECT
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD8A | 1 hits |
| 2 | CYCS | 1 hits |
| 3 | FAS | 1 hits |
| 4 | FASLG | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15943778 | Elevated cytotoxic effector molecule expression (Fas ligand, perforin, granzyme B) indicates T-cell mediated graft destruction by cytotoxic and cytolytic mechanisms within 48 to 72 h after transplantation. |
| 2 | 16180659 | The purpose of this study was to compare mRNA levels of the cytotoxic lymphocyte (CL) gene products: granzyme B (GB), perforin (P), and fas ligand (FasL) in patients with long-term type 1 diabetes and healthy controls. |
| 3 | 16873683 | Perforin and granzyme B impaired insulin secretion from islet cells, and this was accompanied by cytochrome c release, caspase activation, and DNA fragmentation. |
| 4 | 18483268 | Treatment with 1D11 increased infiltration of natural killer cells and T cells at the metastatic site, and enhanced expression of coactivators (NKG2D) and cytotoxic effectors (perforin and granzyme B) on CD8+ T cells. |