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Gene Information
Gene symbol: HADH
Gene name: hydroxyacyl-CoA dehydrogenase
HGNC ID: 4799
Synonyms: HADH1, SCHAD
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CS | 1 hits |
| 2 | FOXA2 | 1 hits |
| 3 | INS | 1 hits |
| 4 | KCNJ11 | 1 hits |
| 5 | NFKB1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7050060 | HADH activity was increased in the normal and diabetic insulin-treated trained groups, but because of its already high activity in the diabetic diaphragm, it did not require an adaptation. |
| 2 | 15894466 | To determine the underlying mechanisms of these metabolic malfunctions, we studied mitochondrial respiration, uncoupled respiration and oxidative enzyme activities (citrate synthase (CS), 3-hydroxy-acyl-CoA-dehydrogenase activity (HAD)) before and after acute exposure to insulin and/or palmitate in myotubes established from healthy lean and obese subjects and T2D patients. |
| 3 | 17095651 | Testing included 90 min of cycle ergometry at 60% Vo(2 peak) with preexercise muscle biopsies analyzed for IMCL and mitochondrial size/area using electron microscopy and short-chain beta-hydroxyacyl-CoA dehydrogenase (SCHAD) and citrate synthase (CS) enzyme activity. |
| 4 | 17491019 | This study examines HADHSC expression in purified rat beta cells and investigates whether its selective suppression elevates insulin release. |
| 5 | 19013780 | To clarify the effects of gamma-oryzanol in mice or the effects of HADs on the underlying mechanisms of adiponectin secretion, we further investigated the effect of HADs on adiponectin secretion in the NF-kappaB activation state. |
| 6 | 20923481 | In the present study, we investigated the mechanism underlying HADHSC-mediated regulation of insulin secretion. |
| 7 | 20923481 | Knockdown of HADHSC increased both fuel- (glucose or leucine plus glutamine) and non-fuel (high KCl)-induced insulin secretion. |
| 8 | 20923481 | Enhanced glucose-stimulated insulin secretion (GSIS) induced by HADHSC knockdown was independent of changes in cytosolic Ca(2+) and also occurred in the presence of fatty acids. |
| 9 | 20923481 | Insulin secretion promoted by both fuel and non-fuel stimuli is negatively regulated by HADHSC. |
| 10 | 15631623 | Molecular analyses have demonstrated that Foxa2 is an important regulator of the genes encoding Sur1, Kir6.2 and Schad (short chain L-3-hydroxyacyl-CoA dehydrogenase), mutation of which causes PHHI in humans. |