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Gene Information
Gene symbol: HCRT
Gene name: hypocretin (orexin) neuropeptide precursor
HGNC ID: 4847
Synonyms: PPOX, OX
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FOS | 1 hits |
| 2 | GHRL | 1 hits |
| 3 | HTR1B | 1 hits |
| 4 | INS | 1 hits |
| 5 | LEP | 1 hits |
| 6 | NPY | 1 hits |
| 7 | PMCH | 1 hits |
| 8 | POMC | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11147774 | We investigated activation of orexin and other neurons during insulin-induced hypoglycemia using the immediate early gene product Fos. |
| 2 | 12663466 | Orexin increased [Ca(2+)](i) and leptin attenuated ghrelin-induced [Ca(2+)](i) increases in the majority (80%) of ghrelin-responsive NPY neurons. |
| 3 | 12663466 | The integration of stimulatory effects of ghrelin and orexin and inhibitory effect of leptin may play an important role in the regulation of the activity of NPY neurons and thereby feeding. |
| 4 | 16959056 | Moreover, CP 94253 (5-10 mg/kg), a selective 5-HT1B receptor agonist, exerted appetite-suppressing effects and significantly increased hypothalamic pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) gene expression and decreased hypothalamic orexin gene expression. |
| 5 | 16959056 | These results suggest that fluvoxamine and inactivation of 5-HT2C receptors exert feeding suppression through activation of 5-HT1B receptors, and that 5-HT1B receptors up-regulate hypothalamic POMC and CART gene expression and down-regulate hypothalamic orexin gene expression in mice. |
| 6 | 19489767 | In addition, a new functional role of orexin is emerging in the regulation of insulin and leptin sensitivities responsible for whole-body glucose metabolism. |
| 7 | 19489767 | These suggest that hyperglycaemia due to insulin insensitivity during ageing or by habitual consumption of a high-fat diet leads to the reduction in orexin expression in the hypothalamus, thereby further exacerbating peripheral insulin resistance. |
| 8 | 20871474 | Propranolol, a ?-adrenergic receptor antagonist, significantly (P<0.04) reduced the stimulatory effect of orexin B on insulin secretion. |
| 9 | 12239605 | Orexin (1 nmol/mouse) significantly increased oxygen consumption, while MCH (1 nmol/mouse) had no significant effect compared to ACSF-treated controls. |