- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: HGS
Gene name: hepatocyte growth factor-regulated tyrosine kinase substrate
HGNC ID: 4897
Synonyms: Hrs, ZFYVE8, Vps27
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GRB10 | 1 hits |
| 2 | INS | 1 hits |
| 3 | KDR | 1 hits |
| 4 | RPS27A | 1 hits |
| 5 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17445799 | Here, we investigate the role of Hepatocyte growth factor-Regulated tyrosine kinase Substrate (Hrs), a regulator of RTK trafficking, in VEGF and insulin signaling. |
| 2 | 17445799 | The UIM (Ubiquitin Interacting Motif) domain of Hrs is required for Hrs-induced increases in VEGF-R2, but not in IR. |
| 3 | 17445799 | We show that the UIM domain is required for Hrs phosphorylation in response to VEGF, but not to insulin. |
| 4 | 17445799 | Finally, we demonstrate that Hrs inhibits Nedd4-mediated VEGF-R2 degradation and acts additively with Grb10. |
| 5 | 17445799 | We conclude that Hrs is a positive regulator of VEGF-R2 and IR signaling and that ectopic expression of Hrs protects both VEGF-R2 and IR from degradation. |