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Gene Information
Gene symbol: HK2
Gene name: hexokinase 2
HGNC ID: 4923
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | COL1A1 | 1 hits |
| 2 | CTGF | 1 hits |
| 3 | INS | 1 hits |
| 4 | PNPLA3 | 1 hits |
| 5 | PRKAA1 | 1 hits |
| 6 | SST | 1 hits |
| 7 | TSPYL2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7883122 | Hexokinase II (HKII) is the predominant hexokinase isozyme expressed in insulin-responsive tissues. |
| 2 | 9519744 | In response to 40 mU insulin, HKII mRNA in lean control subjects was increased 1.48 +/- 0.18-fold (P < 0.05) but failed to increase significantly in the obese (1.12 +/- 0.24) or NIDDM (1.14 +/- 0.18) groups. |
| 3 | 9519744 | In response to 240 mU insulin, HKII mRNA was increased in all groups (control subjects 1.48 +/- 0.18, P < 0.05 vs. basal, obese 1.30 +/- 0.16, P < 0.05, and NIDDM 1.25 +/- 0.14, P < 0.05). |
| 4 | 9519744 | Resistance to insulin's metabolic effects extends to its ability to induce HKII expression in obesity and NIDDM. |
| 5 | 12410639 | In L6 myotubes treated for 24 h with insulin there was increased expression of the HK isoform, HKII, and increased glucose phosphorylation without a concomitant increase in glucose transport, indirectly suggesting that phosphorylation of glucose was a target of insulin action [Osawa, Printz, Whitesell and Granner (1995) Diabetes 44, 1426-1432]. |
| 6 | 12663462 | Activation of AMPK has been associated with enhanced expression of key metabolic proteins such as GLUT-4, hexokinase II (HKII), and mitochondrial enzymes, similar to exercise. |
| 7 | 17088412 | In healthy young men, adiponutrin expression is upregulated [corrected] by hyperinsulinemia and is related to basal and/or insulin-stimulated p85alpha PI3K, HKII, adiponectin, and leptin expression levels. |
| 8 | 18562232 | HI, HG and HGHI clamps increased expression of HKII and p85alpha Pi3K while somatostatin did not. |
| 9 | 20962744 | CDA1 small interfering RNA knockdown markedly attenuated, whereas its overexpression increased TGF-? signaling, modulating the expression of TGF-?, TGF-? receptors, connective tissue growth factor, collagen types I, III, IV, and fibronectin genes in HK-2 cells. |