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Gene Information
Gene symbol: HLA-DQB1
Gene name: major histocompatibility complex, class II, DQ beta 1
HGNC ID: 4944
Synonyms: IDDM1, CELIAC1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CELIAC3 | 1 hits |
| 2 | CTLA4 | 1 hits |
| 3 | GAD1 | 1 hits |
| 4 | HLA-A | 1 hits |
| 5 | IDDM2 | 1 hits |
| 6 | IL10 | 1 hits |
| 7 | IL1A | 1 hits |
| 8 | IL2 | 1 hits |
| 9 | IL6 | 1 hits |
| 10 | INS | 1 hits |
| 11 | TCF7L2 | 1 hits |
| 12 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 2606746 | In Caucasoids HLA-DQB1 genes encoding amino acids other than aspartic acid at position 57 of the DQ beta chain (non-Asp-57) are associated with susceptibility to develop insulin-dependent diabetes mellitus (IDDM), while resistance is associated with aspartic acid at this residue (Asp-57). |
| 2 | 1688068 | Some alleles of the HLA-DQB1 and DQA1 loci are preferentially associated with susceptibility to type 1 (insulin-dependent) diabetes mellitus (IDDM). |
| 3 | 1520483 | Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease and susceptibility to both IDDM and IgA deficiency is associated with HLA DQB1 alleles encoding non-Asp amino acids at position 57. |
| 4 | 8248212 | These data provide new limits for IDDM susceptibility to the 190-kb interval between TAP1 and HLA-DQB1. |
| 5 | 8106272 | Multivariate analysis showed that HLA-DQB1 genotypes had a more significant impact on antibodies to GAD than either duration or age of onset of IDDM. |
| 6 | 7858104 | We determined the HLA-DQB1 genotypes by denaturing gradient gel electrophoresis (DGGE) and/or sequence-specific primers (SSP) techniques to assess the possible interactions between INS and HLA. |
| 7 | 7619493 | We describe a method for the detection of two type 1 (insulin-dependent) diabetes susceptibility (*0201, *0302) alleles and two protective (*0301, *0602/0603) alleles of the HLA-DQB1 gene on the human major histocompatibility complex (MHC). |
| 8 | 16567828 | This study aimed to investigate whether the susceptibility to CD in diabetic children is modified by positivity for HLA-DQB1*02-DQA1*05 and DQB1*0302-DQA1*03 and by alleles of single nucleotide polymorphisms within the genes encoding CTLA4, transforming growth factor (TGF)-beta, tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, interleukin (IL)-1, IL-2, IL-6, and IL-10. |
| 9 | 16567828 | The best-fitted model showed that risk of CD is increased by presence of HLA-DQB1*02-DQA1*05 (odds ratio 4.5 [95% CI 1.8-11], for homozygosity, and 2.0 [1.1-3.7], for a single dose) and also independently by TNF -308A (1.9 [1.1-3.2], for phenotypic positivity), whereas IL1-alpha -889T showed a weak negative association (0.6 [0.4-0.9]). |
| 10 | 16567828 | The results indicate that the risk of CD in children with type 1 diabetes is significantly modified both by the presence of HLA-DQB1*02-DQA1*05 and by a variant of another gene within the major histocompatibility complex, the TNF -308A. |
| 11 | 21374549 | Both strains are common the RT1 (u) haplotype of major histocompatibility complex (MHC) which is essential for type 1 diabetes development in BB rats ( IDDM1). |
| 12 | 19143813 | Preliminary analyses confirm that HLA-B (at 31.4 Mb), HLA-A (at 30.0 Mb) are associated with T1D independently of the class II genes HLA-DRB1 and HLA-DQB1 (P = 6.0 x 10(-17) and 8.8 x 10(-13), respectively). |
| 13 | 21672010 | The TCF7L2 was associated with susceptibility for gestational diabetes independently of the presence of HLA-DQB1*0602 and islet cell autoantibodies and other factors such as maternal age, number of pregnancies, family history of diabetes and other HLA-DQ genotypes. |