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Gene Information
Gene symbol: HMBS
Gene name: hydroxymethylbilane synthase
HGNC ID: 4982
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | NFKB1 | 1 hits |
| 2 | PPARA | 1 hits |
| 3 | TNF | 1 hits |
| 4 | UBB | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17052186 | We showed that UBB+1 causes UPS dysfunction, aggregation and apoptotic cell death. |
| 2 | 19144543 | Because the ubiquitin-proteasome pathway (UPS) is required for activation of nuclear factor kappa beta (NFkB), a transcription factor that regulates inflammatory genes, we evaluated the UPS activity, NFkB activation, and tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine, in ischemic specimens of diabetic myocardium and relate them to the glycemic control (HbA(1c)), oxidative stress (nitrotyrosine, a modified amino acid produced by reactive O(2)), and cardiac outcome (echocardiographic parameters). |
| 3 | 18551186 | Here we review the current knowledge of the interactions between the UPS and PPARs in light of the potential implications for their effects on cell fate and tumorigenesis. |