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Gene Information
Gene symbol: HNF1B
Gene name: HNF1 homeobox B
HGNC ID: 11630
Synonyms: LFB3, VHNF1, HNF1beta, MODY5
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ABCC8 | 1 hits |
| 2 | CDH16 | 1 hits |
| 3 | HMX1 | 1 hits |
| 4 | HNF1A | 1 hits |
| 5 | INS | 1 hits |
| 6 | KCNJ11 | 1 hits |
| 7 | NNMT | 1 hits |
| 8 | SLC2A2 | 1 hits |
| 9 | SOX9 | 1 hits |
| 10 | SRA1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 9369450 | Thus, the synergistic effects of HNF-1beta and the GR on dexamethasone-stimulated promoter activity require that they are bound to the HNF-1 site and the GRE, respectively, and may involve protein-protein interactions between the transcription factors, or between them and the basal transcription machinery or a steroid receptor coactivator. |
| 2 | 10748140 | Coexpression of the pGL+74 (+74 to +301) construct with the HNF1alpha and HNF3beta expression vectors in NIH 3T3 cells showed the synergistic effect on GLUT2 promoter activity compared with the expression of HNF1alpha, HNF3beta, or a combination of HNF1beta and HNF3beta. |
| 3 | 15142986 | Human mutations in HNF1alpha or HNF1beta lead to maturity-onset diabetes of the young (MODY3 and MODY5, respectively), and patients present with impaired glucose-stimulated insulin secretion. |
| 4 | 15486044 | Cotransfection of a HNF-1beta expression plasmid increased NNMT promoter activity significantly in both HNF-1beta-positive and -negative thyroid cancer cell lines and Hep G2 liver cancer cells. |
| 5 | 16873704 | We examined the association of variants in genes encoding several transcription factors (TCF1, TCF2, HNF4A, ISL1, IPF1, NEUROG3, PAX6, NKX2-2, NKX6-1, and NEUROD1) and genes encoding the ATP-sensitive K(+) channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) with type 2 diabetes in a Japanese cohort of 2,834 subjects. |
| 6 | 12217876 | However, expression of a gain-of-function HNF-1beta mutant stimulates Ksp-cadherin promoter activity in transfected cells, whereas expression of a dominant-negative mutant inhibits activity. |
| 7 | 12217876 | These studies identify Ksp-cadherin as the first kidney-specific promoter that has been shown to be regulated by HNF-1beta. |
| 8 | 16837621 | Induction of WT HNF1beta also inhibited the insulin secretory response to nutrient stimuli, membrane depolarisation or activation of protein kinases A and C and this correlated with a significant decrease in pancrease-duodenum homeobox-1 protein levels. |
| 9 | 21829703 | Employing two genetic models of temporally-controlled Sox9 inactivation in pancreatic progenitor cells, we demonstrate that contrary to in vitro findings, Sox9 is not required for Tcf2, Hnf6, or Foxa2 expression in vivo. |