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Gene Information

Gene symbol: HPSE

Gene name: heparanase

HGNC ID: 5164

Synonyms: HPA, HSE1, HPSE1

Related Genes

#	Gene Symbol	Number of hits
1	ALB	1 hits
2	INS	1 hits
3	KDR	1 hits
4	MMP2	1 hits
5	PIK3CG	1 hits
6	SDC1	1 hits
7	VEGFA	1 hits

Related Sentences

#	PMID	Sentence
1	15806157	In addition, we show that the reduction in tumor angiogenesis is correlated with a reduced association of VEGF-A with its receptor VEGF-R2 on the tumor endothelium, implicating heparanase in the mobilization of matrix-associated VEGF.
2	17609509	The objectives of this study were to determine if heparanase is induced by high glucose in endothelial cells and if heparin and/or insulin or basic fibroblast growth factor (bFGF) affect this upregulation.
3	20950809	In addition, heparanase staining co-localized with staining for CD45 and MMP-2 within atherosclerotic plaques.
4	21461610	In the present study, we investigated the effect of AGE-bovine serum albumin (AGE-BSA) on heparanase expression in human microvascular endothelial cells (HMVECs) and the underlying molecular mechanisms.
5	21461610	Moreover, pretreatment with inhibitors of nuclear factor-?B (NF-?B) or PI3-kinase did not affect heparanase expression induced by AGE-BSA.
6	21600934	Albumin and advanced glycation end-product, but not high glucose levels, increased heparanase expression in adult tubular cells via the AKT/PI3K signaling pathway.
7	21600934	In fact, heparanase regulates the gene expression of syndecan-1, the most abundant heparan sulfate-proteoglycans in tubular cells.
8	21364956	Utilizing an in vitro system, we show that insulin stimulates heparanase secretion by kidney 293 cells, and even higher secretion is observed when insulin is added to cells maintained under high glucose conditions.