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Gene Information
Gene symbol: HRAS
Gene name: v-Ha-ras Harvey rat sarcoma viral oncogene homolog
HGNC ID: 5173
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACACA | 1 hits |
| 2 | CDKN1A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19874425 | Our studies show that metformin treatment (1) significantly inhibited proliferation of diverse chemo-responsive and -resistant ovarian cancer cell lines (A2780, CP70, C200, OV202, OVCAR3, SKVO3ip, PE01 and PE04), (2) caused cell cycle arrest accompanied by decreased cyclin D1 and increased p21 protein expression, (3) activated AMPK in various ovarian cancer cell lines as evident from increased phosphorylation of AMPK? and its downstream substrate; acetyl co-carboxylase (ACC) and enhanced ?-oxidation of fatty acid and (4) attenuated mTOR-S6RP phosphorylation, inhibited protein translational and lipid biosynthetic pathways, thus implicating metformin as a growth inhibitor of ovarian cancer cells. |