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Gene Information
Gene symbol: HSF1
Gene name: heat shock transcription factor 1
HGNC ID: 5224
Synonyms: HSTF1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CYBA | 1 hits |
| 2 | DUOX1 | 1 hits |
| 3 | HSPA1A | 1 hits |
| 4 | INS | 1 hits |
| 5 | NOX1 | 1 hits |
| 6 | SERPINE1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17259369 | Treatment with glycated LDL increased the expression of HSF1 and Hsp-70 compared with LDL in subconfluent HCAECs or HUVECs, and that was associated with an increase of PAI-1 expression. |
| 2 | 17259369 | The transfection of HSF1 gene enhanced the expression of PAI-1 in endothelial cells. |
| 3 | 17259369 | The results suggest that HSF-1 is involved in glycated LDL-induced upregulation of PAI-1 in subconfluent vascular endothelial cells through the binding of HSF1 to PAI-1 promoter. |
| 4 | 18597060 | OxVLDL stimulated the expression of PAI-1 from MEF of wild-type mice, but failed to increase PAI-1 expression in MEF of HSF1-knockout mice. |
| 5 | 18597060 | The results indicate that oxVLDL increased PAI-1 expression, and HSF1 mediates the transcription of PAI-1 in cultured vascular EC or fibroblasts. |
| 6 | 19401454 | Diphenyleneiodonium, a NOX inhibitor, prevented the increases of the expression of HSF1 and PAI-1 in EC induced by oxidized LDLs. |
| 7 | 19401454 | Small-interference RNA (siRNA) for p22(phox), an essential subunit of NOX, prevented oxidized LDL-induced expression of NOX2, HSF1, and PAI-1 in EC. |
| 8 | 19401454 | The results of the present study indicate that oxidized LDL-induced expression of NOX may lead to the elevated release of reactive oxygen species, the activation of HSF1, and the enhancement of the transcription of PAI-1 gene in cultured vascular EC. |
| 9 | 19883616 | We found that adding a small amount of glucose to the medium (2%) shortened the life span of C. elegans by inhibiting the activities of life span-extending transcription factors that are also inhibited by insulin signaling: the FOXO family member DAF-16 and the heat shock factor HSF-1. |
| 10 | 20630999 | Previous studies in our laboratory demonstrated that heat shock factor-1 (HSF1) is involved in glyLDL-induced PAI-1 overproduction in vascular endothelial cells (EC). |
| 11 | 20630999 | Treatment with diphenyleneiodonium, a nicotinamide adenine dinucleotide phosphate oxidase (NOX) inhibitor, blocked glyLDL-induced translocation of H-Ras, elevated abundances of HSF1 and PAI-1 in EC, and increased release of hydrogen peroxide from EC. |
| 12 | 20630999 | Small interference RNA for p22(phox) prevented glyLDL-induced expression of NOX2, HSF1, and PAI-1 in EC. |
| 13 | 21325107 | Activation of HSF1 appears to be important, because the phosphorylation change with heat stress was nearly perfectly correlated with HSP70 increases. |
| 14 | 21325107 | We conclude that increasing HSP70, potentially through targeting hyperglycemia-related deficits in HSF1 induction and activation in the liver, is a potent and viable strategy to improve glucose tolerance. |