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Gene Information
Gene symbol: HSPB1
Gene name: heat shock 27kDa protein 1
HGNC ID: 5246
Synonyms: HSP27, HSP28, Hs.76067, Hsp25
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | FKBP1A | 1 hits |
| 3 | HSPA1A | 1 hits |
| 4 | HSPD1 | 1 hits |
| 5 | IKBKB | 1 hits |
| 6 | IL6 | 1 hits |
| 7 | JUN | 1 hits |
| 8 | MAPK1 | 1 hits |
| 9 | MAPK10 | 1 hits |
| 10 | MAPK8 | 1 hits |
| 11 | S100A1 | 1 hits |
| 12 | TGFB1 | 1 hits |
| 13 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10814778 | Upregulation of hsp27, however, was primarily induced by immunoregulatory cytokines like IL-4, IL-6 and TGF-beta whereas alphaB-crystallin expression was found to be enhanced by the pro-inflammatory cytokine TNF-alpha only. |
| 2 | 10814778 | These results show that in human astrocytes induced expression of hsp27 and alphaB-crystallin is dependent on the presence of a defined set of stimuli, while induced expression of hsp60 is a much less selective event. |
| 3 | 16309849 | Heat shock proteins Hsp27 and Hsp72 have the potential to prevent the activation of IKK-beta and JNK, respectively; this suggests that induction of heat shock proteins may blunt the adverse impact of fat overexposure on insulin function. |
| 4 | 16421517 | Phosphorylated p38 (pp38) mitogen-activated protein kinase (MAPK) regulates heat shock protein 25 (HSP25), stabilizing fibrillar actin (FA) and preventing cleavage to G-actin (GA). |
| 5 | 17047923 | The concentration of anti-apoptotic heat shock protein (HSP) 70 in DRG was decreased, whereas concentrations of Bcl-xl and HSP27 were unaltered. |
| 6 | 18204486 | Our results suggested that protection against development of diabetic nephropathy by curcumin treatment involved changes in post-translational modifications of histone H3, expression of HSP-27 and MAP kinase p38 in diabetic kidney. |
| 7 | 19073766 | Heat treatment resulted in decreased activation of Jun NH2-terminal kinase (JNK) and inhibitor of kappaB kinase (IKK-beta), stress kinases implicated in insulin resistance, and upregulation of HSP72 and HSP25, proteins previously shown to inhibit JNK and IKK-beta activation, respectively. |
| 8 | 19726550 | Thus PTEN or Hsp25 could serve as potential therapeutic targets to modulate Akt activation and control p38 MAPK-mediated diabetic complications. |
| 9 | 20360867 | Using proteomic and ultrastructural approaches, multiple alterations in the expression of proteins involved in oxidative stress (catalase, superoxide dismutase 1, Hsp27, Hsp60, ATP synthase delta chain, and flavin reductase), aerobic and anaerobic glycolysis (ACBP, pyruvate kinase muscle isozyme, and phosphoglycerate kinase 1), and intracellular signaling (stratifin-14-3-3, S100-calcyclin, cathepsin, and PPI rotamase) as well as endothelial vascular abnormalities were identified in T1D and T1D+ESRD patients. |