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Gene Information
Gene symbol: IFNGR2
Gene name: interferon gamma receptor 2 (interferon gamma transducer 1)
HGNC ID: 5440
Synonyms: AF-1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ERAL1 | 1 hits |
| 2 | GSTA1 | 1 hits |
| 3 | HDAC9 | 1 hits |
| 4 | NCOR1 | 1 hits |
| 5 | PPARA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11139388 | Since PPARalpha exhibits a strong constitutive transactivating function contained within an N-terminal AF-1 region, it can be speculated that a different set of cofactors might interact with this region of PPARs. |
| 2 | 12482846 | Tamoxifen allows strong ERalpha AF-1 activity, whereas raloxifene allows less and ICI 182,780 (ICI) allows none. |
| 3 | 12482846 | Here, we show that blockade of corepressor histone de-acetylase (HDAC) activity reverses the differential inhibitory effect of SERMs upon AF-1 activity in MCF-7 cells. |
| 4 | 12482846 | An ERalpha mutation (537X) that increases N-CoR binding in the presence of all SERMs blocks AF-1 activity. |
| 5 | 12482846 | An ERalpha mutation (L379R) that decreases N-CoR binding increases AF-1 activity in the presence of ICI and raloxifene and reverses the effect of the 537X mutation. |
| 6 | 18311053 | To understand the molecular mechanism of AF-1 in FXR, we isolated proteins associated with AF-1 by GST pull-down assay using the N-terminal region of FXR and nuclear extracts from HeLa cells. |