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Gene Information
Gene symbol: IGF2BP2
Gene name: insulin-like growth factor 2 mRNA binding protein 2
HGNC ID: 28867
Synonyms: IMP-2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CDKN2B | 1 hits |
| 2 | IGF2 | 1 hits |
| 3 | IGF2BP1 | 1 hits |
| 4 | IGF2BP3 | 1 hits |
| 5 | INS | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20627640 | We analysed here the association between T2D (and related traits) and rs4402960 and rs1470579 in IGF2BP2, and rs46522 and rs6949019 (marking IGF2BP1 and IGF2BP3 respectively) from the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study (N approximately 2500 aged 65-96 years). |
| 2 | 20627640 | The lower fasting insulin levels and the impaired beta-cell function associated with IGF2BP2 SNPs are independent of obesity phenotypes. |
| 3 | 17463246 | With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D-in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1-and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. |
| 4 | 21576258 | We describe the ability of mammalian target of rapamycin (mTOR) to regulate the cap-independent translation of IGF2 mRNA through phosphorylation of IMP2, an oncofetal RNA-binding protein. |
| 5 | 21576258 | Double phosphorylation promotes IMP2 binding to the IGF2 leader 3 mRNA 5' untranslated region, and the translational initiation of this mRNA through eIF-4E- and 5' cap-independent internal ribosomal entry. |