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Gene Information
Gene symbol: IGFBP4
Gene name: insulin-like growth factor binding protein 4
HGNC ID: 5473
Synonyms: IBP4, BP-4, HT29-IGFBP, IGFBP-4
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IGF1 | 1 hits |
| 2 | IGFBP1 | 1 hits |
| 3 | IGFBP2 | 1 hits |
| 4 | IGFBP3 | 1 hits |
| 5 | IGFBP5 | 1 hits |
| 6 | INS | 1 hits |
| 7 | PTH | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 1704481 | This protein, now proposed to be named IGFBP-4, contains two extra cysteines compared with the previously characterized IGFBP-1, -2, and -3, but the alignment of the remaining 18 cysteines is conserved across the four IGFBPs. |
| 2 | 7683646 | Substitution of residues 48-50 with the analogous residues from human insulin (Thr-Ser-Ile) reduced binding to IGFBP-1, -5, and -6 more than 50-fold and to IGFBP-4 by 15-50-fold; binding to IGFBP-2 and -3 was reduced 6-12-fold. |
| 3 | 9061602 | IGF-I, and IGFBP-4 and -5 mRNAs showed site-specific tubular changes whilst remaining unchanged in other parts of the kidney normally expressing the genes: IGF-I and IGFBP-4 mRNAs were reduced in TALs and proximal tubules respectively; IGFBP-5 mRNA was reduced in most distal tubular cells but strongly expressed in a few of these cells. |
| 4 | 9421396 | The results suggest that high glucose acts on pSMC to induce a change in IGFBP-4 proteolytic activity, which results in increased IGF-I availability to its receptors thereby enhancing the SMC proliferative response. |
| 5 | 9795371 | Furthermore, biochemical markers indicating bone loss (ICTP) and increased bone turnover (PTH, OSC) correlated positively with IGFBP-1 and IGFBP-4 but negatively with IGF-I, IGFBP-3 and IGFBP-5, while the opposite was observed with bone formation markers (PICP, B-ALP) and vitamin D3 metabolites. |
| 6 | 11739083 | Substitution of the P3 region for the P4 region in IGFBP-4 (IGFBP-4(3)) increased the ability of the protease to digest IGFBP-4(3); substitution of the P4 region for the P3 region in IGFBP-3 (IGFBP-3(4)) decreased the digestion of IGFBP-3(4). |
| 7 | 16180585 | Protein level of IGFBP-3 in muscle of diabetic C-line mice was augmented by approx. 28% when compared to the control, whereas the expression of IGFBP-4 and -5 was not modified by STZ-diabetes. |