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Gene Information
Gene symbol: IGFBP7
Gene name: insulin-like growth factor binding protein 7
HGNC ID: 5476
Synonyms: MAC25, IGFBP-7, PSF, FSTL2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | CGB | 1 hits |
| 3 | CRP | 1 hits |
| 4 | DES | 1 hits |
| 5 | IGFBP3 | 1 hits |
| 6 | INS | 1 hits |
| 7 | IRS1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 9388210 | IGFBP-7 blocks insulin binding to the insulin receptor and thereby inhibiting the earliest steps in insulin action, such as autophosphorylation of the insulin receptor beta subunit and phosphorylation of IRS-1, indicating that IGFBP-7 is a functional insulin-binding protein. |
| 2 | 9388210 | Like IGFBP-7, an NH2-terminal fragment of IGFBP-3 (IGFBP-3((1-87))), also binds insulin with high affinity and blocks insulin action. |
| 3 | 16596638 | In addition, we showed that human chorionic gonadotropin (hCG) has distinct effects on their expression and production. hCG enhances the expression and production of TIMP-1, whereas it downregulates the expression of CTGF and Mac25. |
| 4 | 16873698 | IGF-binding protein (IGFBP)-related protein 1 (IGFBP-rP1) has been shown to bind both IGFs and insulin, albeit with low affinity, and to inhibit insulin signaling. |
| 5 | 16873698 | We hypothesized that IGFBP-rP1 is associated with insulin resistance and components of the IGF system in humans. |
| 6 | 16873698 | Among nondiabetic men, those in the highest quartile for circulating IGFBP-rP1 exhibited decreased S(i) and adiponectin (both P < 0.01) as well as increased CRP and sTNFR2 (both P < 0.05). |
| 7 | 16873698 | These findings show for the first time that circulating IGFBP-rP1 is increased with insulin resistance, and they also suggest novel interactions between IGFBP-rP1 and the IGF system in humans. |
| 8 | 20630940 | IGFBP-rP1 was absent from podocytes of normal mice and was expressed in podocytes and pseudocrescents of transgenic mice, where it was coexpressed with desmin, a podocyte injury marker. |