- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: IHG1
Gene name: iris hypoplasia with glaucoma 1
HGNC ID: 5954
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | HSPA5 | 1 hits |
| 2 | INS | 1 hits |
| 3 | NRF1 | 1 hits |
| 4 | SMAD3 | 1 hits |
| 5 | TFAM | 1 hits |
| 6 | TGFB1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18508967 | IHG-1 was found to amplify TGF-beta1-mediated transcriptional activity by increasing and prolonging phosphorylation of Smad3. |
| 2 | 18508967 | Conversely, inhibition of endogenous IHG-1 with small interference RNA suppressed transcriptional responses to TGF-beta1. |
| 3 | 18508967 | In summary, IHG-1, which increases in diabetic nephropathy, may enhance the actions of TGF-beta1 and contribute to the development of tubulointerstitial fibrosis. |
| 4 | 19155609 | Using this device, we showed that IHG induced more serious impairment in INS-1 cells than did SHG, and adiponectin partially rescued INS-1 cells from glucotoxicity-induced apoptosis, dysfunction and reduction of insulin gene expression. |
| 5 | 21784897 | Conversely, inhibition of IHG-1 expression decreased mitochondrial mass, downregulated mitochondrial proteins, and PGC-1?-regulated transcription factors, including nuclear respiratory factor 1 and mitochondrial transcription factor A (TFAM), and reduced activity of the TFAM promoter. |
| 6 | 21945929 | In comparison to both the SHG and control groups, IHG conditions induced a more significant impairment of insulin release and calcium influx in response to 1nM GLP-1 treatment. |
| 7 | 21945929 | In addition, the activity of caspase 3/7 as well as the gene expression of binding protein (Bip) and C/EBP homologous protein (CHOP), molecular markers of ER stress, was significantly higher in IHG-treated cells than in SHG-treated cells. |