Ignet

Gene Information

Gene symbol: IL12A

Gene name: interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)

HGNC ID: 5969

Synonyms: CLMF, IL-12A, p35, NFSK

Related Genes

#	Gene Symbol	Number of hits
1	ADIPOQ	1 hits
2	ALOX12	1 hits
3	ALOX15B	1 hits
4	ATF3	1 hits
5	CCR5	1 hits
6	CD4	1 hits
7	CD86	1 hits
8	IFNG	1 hits
9	IL10	1 hits
10	IL12B	1 hits
11	IL15	1 hits
12	IL18	1 hits
13	IL1B	1 hits
14	IL4	1 hits
15	IL6	1 hits
16	IL7	1 hits
17	IL9	1 hits
18	MS	1 hits
19	NOS2A	1 hits
20	SOCS6	1 hits
21	SUMO2	1 hits
22	TBX21	1 hits

Related Sentences

#	PMID	Sentence
1	8694804	Incubation of the macrophage cell line IC 21 with interferon-gamma gave rise to both interleukin-12 p40 mRNA and nitric oxide production.
2	8694804	The concurrent addition of the nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine inhibited nitrite production and in parallel completely suppressed interleukin-12 p40 mRNA formation.
3	8694804	This indicated that endogenous nitric oxide synthase activity was required for IL-12 p40 gene expression.
4	9341777	To study the involvement of Th1 and Th2 cells in the initiation and progression of IDDM, we targeted endogenous IL-12 by administration of (p40)2 in NOD mice.
5	10990075	Cyclophosphamide treatment decreased IL-12, IL-1beta, IL-2, IFN-gamma and TNF-alpha gene expressions in mononuclear spleen cells but IL-4 gene expression increased.
6	11422905	The treatment with MoAb to IL-12(p40) reduced the insulitis with diabetes which was associated with a decrease in the mRNA expression for IL-12(p40), IL-18 and IFN-gamma, and an increase of IL-4 mRNA expression in the spleen.
7	11508268	Although MFP14 reduced anti-CD3 and/or LPS-induced blood levels of IFN-gamma, TNF-alpha and IL-12 it increased IL-4 and IL-10.
8	11972887	Allele 1 of an IL12B 3'UTR single-nucleotide polymorphism leads to increased expression of IL-12, and was recently implicated in susceptibility for type 1 diabetes (T1D).
9	11978632	Thus, a short treatment of adult NOD mice with an analog of 1,25-dihydroxyvitamin D(3) inhibits IL-12 production, blocks pancreatic infiltration of Th1 cells, enhances CD4(+)CD25(+) regulatory cells, and arrests the progression of type 1 diabetes, suggesting its possible application in the treatment of human autoimmune diabetes.
10	14525620	The 29 known interleukins were clustered into three groups: noxious (the "bad", 8 members), comprising IL-1, IL-2, IL-6, IL-7, IL-8, IL-15, IL-17 and IL-18; protective (the "good", 5 members), comprising IL-4, IL-10, IL-11, IL-12 and IL-13; and "aloof", comprising IL-5, IL-9, IL-14, IL-16 and IL-19 through IL-29 (15 members).
11	15988104	Interleukin (IL)-12 is thought to play an important role in the development of atherosclerosis and recently, polymorphism of the 3'-untranslated region of the IL-12 p40 gene (A1188C) was reported to be associated with diabetes and multiple sclerosis.
12	16038020	Compared to previous reports our analysis provides a new view on the IL-12 induced changes on CD4(+) T cells underscoring the importance of creating and combining the data generated at various levels to build a comprehensive view of a given biological process of the cell.
13	16367949	In the present study, there was a progressive and significant increase in the expression levels of IL-15, together with Th1 cytokines (IL-12 and IFN-gamma) during SPTB but a significant decrease during LTB.
14	16367949	IL-15 is known to up-regulate the production of proinflammatory cytokines, IL-1beta, IL-8, IL-12, IL-17, IFN-gamma and TNF-alpha and has an inhibitory effect on activation-induced cell death.
15	17785797	In primary macrophages from mice with a targeted deletion of the atf3 gene (ATF3-knockout (KO)), TLR-stimulated levels of IL-12 and IL-6 were elevated relative to responses in wild-type macrophages.
16	19414403	Rat splenocytes stimulated with alpha-GalCer preferentially produced IL-12, whereas mouse splenocytes preferentially produced IL-4. alpha-GalCer elicits species-specific cytokine responses in iNKT cells.
17	21094135	Gene and protein expression for ALOX15a, ALOX15b and ALOX 12 were measured by real-time PCR and western blotting in adipocytes and stromal vascular fractions (SVF) from om and sc adipose tissue along with the mRNA expression of the downstream cytokines IL-12a, IL-12b, IL-6, IFN? and the chemokine CXCL10.
18	21081706	Sitagliptin also reduced adipocyte mRNA expression of inflammatory genes, including IL-6, TNF?, IL-12(p35), and IL-12(p40), 2.5- to fivefold as well as 12-lipoxygenase protein expression.
19	21368230	Naive Tregs were capable of upregulating expression of Th1-associated T-bet, CXCR3, and IFN-? in response to IL-12.
20	9930925	Indeed, administration of a natural interleukin-12 antagonist suppressed the progression of islet inflammation and concomitant upregulation of the inducible nitric oxide synthase.
21	20406305	The inhibition of EAE by PPARdelta agonists was also associated with a decrease in IL-12 and IL-23 and an increase in IL-4 and IL-10 expression in the CNS and lymphoid organs.
22	22069273	Although mSUMO2 overexpression in dendritic cells did not alter the expression of major histocompatibility complex class II proteins or B7, IL-1, IL-6 and IL-7, IL-12 expression decreased, switching Th1-directed immune responses into Th2 responses.
23	22069275	STAT4 is involved in the signalling of interleukin-12 and ?IFN, as well as interleukin-23.
24	22069288	Bone marrow-derived dendritic cells displayed a different surface marker profile in the presence of 1,25(OH)(2) D(3) with decreased MHC II, CD86 and CD80 and increased CCR5, DEC205, F4/80 and CD40, as well as lower IL6 and IL12 expression upon LPS/IFN? stimulation.