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Gene Information
Gene symbol: IL17C
Gene name: interleukin 17C
HGNC ID: 5983
Synonyms: IL-17C, CX2, IL-21, MGC126884, MGC138401
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD8A | 1 hits |
| 2 | COL1A1 | 1 hits |
| 3 | IL17A | 1 hits |
| 4 | IL2 | 1 hits |
| 5 | IRF4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18779574 | IL-21 is elevated in several autoimmune diseases, and blocking its action has attenuated disease in MRL/lpr mice and in collagen-induced arthritis. |
| 2 | 19208913 | Conversely, overexpression of IL-21 in pancreatic beta-cells induced inflammatory cytokine and chemokines, including IL-17A, IL17F, IFN-gamma, monocyte chemoattractant protein (MCP)-1, MCP-2, and interferon-inducible protein-10 in the pancreas. |
| 3 | 20498357 | Furthermore, the addition of TGF-beta to the Th17-inducing cytokines (IL-1beta, IL-6, IL-21, IL-23) that induce memory cells to secrete IL-17, resulted in the marked coexpression of IL-9 in IL-17 producing memory cells. |
| 4 | 21111405 | Interferon Regulatory Factor (IRF4) is a crucial regulator of IL-17 and IL-21 production. |
| 5 | 21430227 | In this paper, we report that prior stimulation with IL-15 and IL-21 also enables CD8(+) T cells to respond to weakly agonistic TCR ligands, resulting in proliferation, cytokine secretion, and cytolytic activity. |
| 6 | 21593413 | Whereas IL-2 promotes development of regulatory T cells and confers protection from autoimmune disease, IL-21 promotes differentiation of Th17 cells and is implicated in several autoimmune diseases, including type 1 diabetes and systemic lupus erythematosus. |