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Gene Information
Gene symbol: INPP5D
Gene name: inositol polyphosphate-5-phosphatase, 145kDa
HGNC ID: 6079
Synonyms: SHIP, hp51CN
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CRP | 1 hits |
| 2 | IGF1 | 1 hits |
| 3 | INS | 1 hits |
| 4 | NOS3 | 1 hits |
| 5 | PIK3CA | 1 hits |
| 6 | PTK2B | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17046573 | In bone marrow-derived MCs (BMMCs) from wild-type as well as SHIP-deficient mice Ins as well as insulin-like growth factor-1 (IGF-I)-triggered intracellular signaling events and MC effector functions were studied. |
| 2 | 17046573 | We also found that Ins/IGF-1 stimulates the tyrosine phosphorylation of SHIP1 and, in keeping with this, Ins/IGF-1-induced PKB phosphorylation is higher in SHIP1-/- BMMCs and is inhibited in SHIP+/+ as well as SHIP1-/- BMMCs with inhibitors of phosphatidylinositol-3-kinase (PI3K). |
| 3 | 19423845 | Furthermore, we find that endothelium express SHIP-1 (Src homology 2 domain-containing inositol 5'-phosphatase 1), that CRP induces SHIP-1 stimulatory phosphorylation in endothelium in culture and in vivo, and that SHIP-1 knockdown by small interfering RNA prevents CRP antagonism of insulin-induced eNOS activation. |
| 4 | 19423845 | Thus, CRP inhibits eNOS stimulation by insulin via FcgammaRIIB and its ITIM, SHIP-1 activation, and resulting blunted activation of Akt. |