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Gene Information

Gene symbol: INPPL1

Gene name: inositol polyphosphate phosphatase-like 1

HGNC ID: 6080

Synonyms: SHIP2

Related Genes

#	Gene Symbol	Number of hits
1	AKT1	1 hits
2	INS	1 hits

Related Sentences

#	PMID	Sentence
1	16842857	SHIP2 negatively regulates insulin signaling relatively specifically via its 5'-phosphatase activity.
2	16842857	Importantly, inhibition of endogenous SHIP2 through the liver-specific expression of a dominant-negative SHIP2 improves glucose metabolism and insulin resistance in diabetic db/db mice.
3	16842857	Taken together, inhibition of endogenous SHIP2 in the whole body appears to be effective at improving the insulin resistance associated with type 2 diabetes and/or obesity.
4	17557929	Inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) is a negative regulator of insulin signalling and has previously been found to be associated with hypertension, obesity and type 2 diabetes in a cohort of families with diabetes in the UK presenting features of metabolic syndrome.
5	19694723	The lipid phosphatase known as SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) plays an important role in the regulation of the intracellular insulin signalling pathway.
6	20829391	When a dominant-negative mutant of SHIP2 was expressed in cultured neurons, insulin signaling was augmented, indicating physiological significance of endogenous SHIP2 in neurons.
7	20829391	To investigate the impact of increased expression of SHIP2 in the brain, we further employed transgenic mice overexpressing SHIP2 and found that increased amounts of SHIP2 induced the disruption of insulin/IGF-I signaling through Akt.
8	20829391	Neuroprotective effects of insulin and IGF-I were significantly attenuated in cultured cerebellar granule neurons from SHIP2 transgenic mice.