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Gene Information
Gene symbol: IRS4
Gene name: insulin receptor substrate 4
HGNC ID: 6128
Synonyms: PY160, IRS-4
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | IGF1 | 1 hits |
| 3 | INS | 1 hits |
| 4 | IRS2 | 1 hits |
| 5 | SLC2A4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10077007 | Our data suggest that IRS-3 and IRS-4 are capable of mediating PI 3-kinase-dependent metabolic actions of insulin in adipose cells, and that IRS proteins play a physiological role in mediating translocation of GLUT4. |
| 2 | 11113178 | Following transduction of IRS-3 or IRS-4, the cells showed a significant decrease in IRS-2 mRNA and protein levels without any change in the IRS-1 protein level. |
| 3 | 11113178 | However, IRS-3- or IRS-4-expressing cells also showed a marked decrease in IRS-1 and IRS-2 phosphorylation compared to the host cells. |
| 4 | 11113178 | IRS-3- or IRS-4-overexpressing cells showed an increase in basal phosphatidylinositol 3-kinase activity and basal Akt phosphorylation, while the IGF-1-stimulated levels correlated well with total tyrosine phosphorylation level of all IRS proteins in each cell line. |
| 5 | 11113178 | These data suggest that IRS-3 and IRS-4 may act as negative regulators of the IGF-1 signaling pathway by suppressing the function of other IRS proteins at several steps. |