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Gene Information
Gene symbol: ITGAL
Gene name: integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
HGNC ID: 6148
Synonyms: LFA-1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD44 | 1 hits |
| 2 | ICAM1 | 1 hits |
| 3 | ICAM3 | 1 hits |
| 4 | IL10 | 1 hits |
| 5 | IL4 | 1 hits |
| 6 | ITGAM | 1 hits |
| 7 | PARP1 | 1 hits |
| 8 | TGFB1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 1355751 | The LFA-1 interaction with its ligand ICAM-1 mediates not only cell adhesion but also signal transduction in immunologic and inflammatory cell responses. |
| 2 | 7836774 | The intercellular adhesion molecule-3 (ICAM-3) has been identified as the third LFA-1 ligand in addition to ICAM-1 and ICAM-2. |
| 3 | 12657834 | In contrast, T cells from anti-ICAM-1/LFA-1-treated mice expressed IFN-gamma, IL-10 and TGF-beta1 but not IL-4. |
| 4 | 12682824 | In type 2 diabetic patients with MVC the basal upregulation of CD11a and CD18 may be related to the PMN spontaneous activation, while the behavior of CD11b may depend on its self-consumption. |
| 5 | 14529360 | Microglial migration is strongly controlled in living brain tissue by expression of the integrin CD11a, which is regulated in turn by PARP-1, proposing that PARP-1 downregulation may therefore be a promising strategy in protecting neurons from this secondary damage, as well. |
| 6 | 10222028 | In support of this interpretation, we found that the accessory molecules CD4, CD44, and B7-1 (all of which are involved in T cell co-stimulation) were cleaved by Phlogenzym, while CD3 and MHC class II molecules (which are involved in the recognition of antigens by T cells) and LFA-1 were unaffected. |