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Gene Information
Gene symbol: KCNJ11
Gene name: potassium inwardly-rectifying channel, subfamily J, member 11
HGNC ID: 6257
Synonyms: Kir6.2, BIR
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ABCC8 | 1 hits |
| 2 | HADH | 1 hits |
| 3 | HNF1A | 1 hits |
| 4 | HNF1B | 1 hits |
| 5 | HNF4A | 1 hits |
| 6 | INS | 1 hits |
| 7 | ISL1 | 1 hits |
| 8 | NEUROD1 | 1 hits |
| 9 | NEUROG3 | 1 hits |
| 10 | NKX2-2 | 1 hits |
| 11 | NKX6-1 | 1 hits |
| 12 | PAX6 | 1 hits |
| 13 | PDX1 | 1 hits |
| 14 | SERPINE1 | 1 hits |
| 15 | TCF7 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21814221 | Variants in USF1, ABCC8, ISL1 and KCNJ11 showed nominal association, while haplotypes in these genes were significantly associated. rs3812704 upstream of NEUROG3 significantly increased risk for type 2 diabetes in normal-weight/lean subjects (OR=1.68 (95%CI 1.25-2.24), P=4.9 × 10(-4)). |
| 2 | 16873704 | We examined the association of variants in genes encoding several transcription factors (TCF1, TCF2, HNF4A, ISL1, IPF1, NEUROG3, PAX6, NKX2-2, NKX6-1, and NEUROD1) and genes encoding the ATP-sensitive K(+) channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) with type 2 diabetes in a Japanese cohort of 2,834 subjects. |
| 3 | 17894829 | Recent studies indicate transcription factor hepatocyte nuclear factor 4 alpha (HNF-4 alpha, HNF4A) modulates the transcription of the pancreatic B-cell ATP-sensitive K+ (KATP) channel subunit Kir6.2 gene (KCNJ11). |
| 4 | 20879971 | These genes include glucokinase (GCK), HLA antigens, insulin receptor (INSR), insulin-like growth factor-2 (IGF2), HNF4A, insulin gene (INS-VNTR), plasminogen activator inhibitor 1 (PAI-1), potassium inwardly rectifying channel subfamily J, member 11 (KCNJ11), hepatocyte nuclear factor-4a (HNF4A). |
| 5 | 21411514 | Congenital hyperinsulinism in infancy (CHI) is characterized by unregulated insulin secretion from pancreatic ?-cells; severe forms are associated with defects in ABCC8 and KCNJ11 genes encoding sulfonylurea receptor 1 (SUR1) and Kir6.2 subunits, which form ATP-sensitive K(+) (K(ATP)) channels in ?-cells. |
| 6 | 15631623 | Molecular analyses have demonstrated that Foxa2 is an important regulator of the genes encoding Sur1, Kir6.2 and Schad (short chain L-3-hydroxyacyl-CoA dehydrogenase), mutation of which causes PHHI in humans. |
| 7 | 21682153 | Genetic testing identified the presence of the de nova V59M and E322K activating mutations in the KCNJ11 gene encoding the sulphonylurea/potassium channel (Kir6.2 subunit) of the insulin beta cell. |
| 8 | 21812222 | Understanding of physiopathology increased this last decade, as many mutations in genes playing critical roles in the development of pancreas, have been described: the most common are chromosome 6q anomalies in the case of TND, and mutations in KCNJ11 and ABCC8 genes encoding the subunit of the insulin cell potassium channel in the case of PND. |