Ignet

Gene Information

Gene symbol: KLRG1

Gene name: killer cell lectin-like receptor subfamily G, member 1

HGNC ID: 6380

Synonyms: MAFA, 2F1, MAFA-L, CLEC15A

Related Genes

#	Gene Symbol	Number of hits
1	FOXA2	1 hits
2	FOXO1	1 hits
3	GCK	1 hits
4	GLIS3	1 hits
5	HMX1	1 hits
6	IL1B	1 hits
7	INS	1 hits
8	IRF1	1 hits
9	ISL1	1 hits
10	JUN	1 hits
11	MAFB	1 hits
12	MAP3K1	1 hits
13	MAPK10	1 hits
14	MLXIPL	1 hits
15	MYC	1 hits
16	NEUROD1	1 hits
17	NFATC2	1 hits
18	NKX2-2	1 hits
19	NR0B2	1 hits
20	PARP1	1 hits
21	PDX1	1 hits
22	SLC2A2	1 hits
23	SOX17	1 hits
24	SST	1 hits
25	STAT1	1 hits
26	TCEAL1	1 hits
27	TRIB3	1 hits
28	TXN	1 hits
29	XBP1	1 hits

Related Sentences

#	PMID	Sentence
1	12368292	Therefore, MafA is a beta-cell-specific and glucose-regulated transcriptional activator for insulin gene expression and thus may be involved in the function and development of beta-cells as well as in the pathogenesis of diabetes.
2	16505238	These data suggest that low-potency PARP inhibitors increase insulin biosynthesis, in part, through a mechanism involving increased MafA gene transcription.
3	17583797	We found here that MafA transcription activity is markedly inhibited by MEKK1 and IL-1beta.
4	17583797	These data suggest that IL-1beta through MEKK1 inhibits INS transcription and does so, at least in part, by decreasing MafA transcriptional activity at the RIPE3b control element.
5	17456846	Using this transgenic approach, we have determined that the Nkx2.2-repressor derivative disrupts endogenous Nkx2.2 expression in adult mice and causes downregulation of the mature beta-cell factors, MafA and Glut2.
6	17510498	FoxO1 inhibits beta cell proliferation through suppression of Pdx1 by competing with FoxA2 and protects against beta cell failure induced by oxidative stress through NeuroD and MafA induction.
7	17938503	MafA is a recently isolated beta-cell-specific transcription factor which functions as a potent activator of insulin gene transcription.
8	18948074	Inhibition of the MAP-kinase JNK mimics the effects of staurosporine on the expression of mafA.
9	19264802	Moreover, Glis3 physically and functionally interacts with Pdx1, MafA and NeuroD1 to modulate Ins2 promoter activity.
10	19264802	Glis3 also may indirectly affect insulin promoter activity through upregulation of MafA and downregulation of Nkx6-1.
11	19805515	Gene expression profiling and immunofluorescent staining demonstrated that the expression of pancreatic hormones and several transcription factors important in endocrine cell development, including Ngn3, MafA, and Pdx1, were significantly decreased in the developing pancreata of Glis3(zf/zf) mutant mice.
12	20424162	IL-1beta also causes increased expression of C/EBP-beta and a reduction of MafA, NFATc2, and Pdx-1 expression in beta cells.
13	20424231	Consistent with these results, overexpression of c-Jun significantly decreased MafA expression, accompanied by suppression of insulin expression.
14	20424231	Importantly, MafA overexpression restored the insulin promoter activity and protein levels that were suppressed by c-Jun.
15	20424231	These results indicate that the decreased insulin biosynthesis induced by c-Jun is principally mediated by the suppression of MafA activity.
16	20424231	It is likely that the augmented expression of c-Jun in diabetic islets decreases MafA expression and thereby reduces insulin biosynthesis, which is often observed in type 2 diabetes.
17	15944145	This study was designed to assess whether palmitate alters the expression and binding activity of the key regulatory factors pancreas-duodenum homeobox-1 (PDX-1), MafA, and Beta2, which respectively bind to the A3, C1, and E1 elements in the proximal region of the insulin promoter.
18	15944145	Combined adenovirus-mediated overexpression of PDX-1 and MafA in islets completely prevented the inhibition of insulin gene expression by palmitate.
19	15944145	These results demonstrate that prolonged exposure of islets to palmitate inhibits insulin gene transcription by impairing nuclear localization of PDX-1 and cellular expression of MafA.
20	18199433	Furthermore, pancreata from MafB deficient (kr(ENU)/kr(ENU)) mice exhibited reduced number of cells expressing insulin, glucagon, PDX-1 and MafA, with only a minor reduction in MafB expressing cells.
21	18199433	Thus, Pax6 acts upstream of MafB, which in turn may trigger the expression of insulin and regulate the PDX-1 and MafA expression required for beta-cell maturation.
22	20934404	We show here that ChREBP inactivation in clonal pancreatic MIN6 ?-cells results in an increase in Pdx-1 expression at low glucose and to a small, but significant, increase in Ins2, GcK and MafA gene expression at high glucose concentrations.
23	20934404	Conversely, adenovirus-mediated over-expression of ChREBP in mouse pancreatic islets results in decreases in Pdx-1, MafA, Ins1, Ins2 and GcK mRNA levels.
24	21076579	The effects of adenovirus-mediated overexpression of TRB3 on insulin, PDX-1 and MafA gene expression in INS-1 cells were measured by Northern blot analysis.
25	21076579	Adenovirus-mediated overexpression of TRB3 also decreased PDX-1 mRNA expression, but did not influence MafA mRNA expression.
26	20980260	STAT1, but not IRF-1, mediates the cytokine-induced loss of the differentiated ?-cell phenotype, as indicated by decreased insulin, Pdx1, MafA, and Glut2.
27	21190012	Important glucose-responsive transcription factors, Mafa and Pdx1, regulate genes involved in insulin synthesis and secretion, and have been implicated in late beta cell development.
28	21190012	After infection with adenovirus expressing MAFA, Pdx1 or green fluorescent protein (Gfp), P2 rat islets were evaluated by RT-PCR and insulin secretion with static incubation and reverse haemolytic plaque assay (RHPA).
29	21190012	At P2 most beta cell genes were expressed at about 10% of adult, but by P7 Pdx1 and Neurod1 no longer differ from adult; by contrast, Mafa expression remained significantly lower than adult through P21.
30	21190012	Overexpression of Pdx1 increased Mafa, Neurod1, glucokinase (Gck) mRNA and insulin content but failed to enhance glucose responsiveness.
31	21099304	We have also identified MafA, a potent Insulin gene regulator, as the first direct target of Isl-1 in ?-cells.
32	19502415	In addition, MafA, a potent regulator of the Insulin gene and beta-cell function, was identified as a direct transcriptional target of Isl-1.
33	20158571	MafA is a pancreatic transcriptional factor that controls ?-cell-specific transcription of the insulin gene.
34	20158571	Our results showed that overexpression of MafA in PDMSCs significantly up-regulated the expression of pancreatic development-related genes (Sox17, Foxa2, Pdx1 and Ngn3).
35	20158571	MafA increased the expression levels of the mRNAs of NKx2.2, Glut2, insulin, glucagons and somatostatin, and further facilitated the differentiation of PDMSCs into insulin(+) cells.
36	20158571	Importantly, the expression of MafA in PDMSCs xenotransplanted into immunocompromised mice improved the restoration of blood insulin levels to control values and greatly prolonged the survival of graft cells in immunocompromised mice with STZ-induced diabetes.
37	20158571	In summary, these data suggest that MafA plays a novel role in the reprogramming of stem cells into pancreatic ?-progenitors, promotes the islet-like characteristics of PDMSCs, as well as functionally enhances insulin production to restore the regulation of blood glucose levels in transplanted grafts.
38	15561947	We do not however find any expression of the late-stage genes (Pax4, Pax6, Isl-1, and MafA) related to beta-cell development, and the cells do not secrete insulin upon the glucose challenge.
39	15664997	MafA, a recently isolated pancreatic beta-cell-specific transcription factor, is a potent activator of insulin gene transcription.
40	16435884	Conditional expression of Smad7 in adult Pdx1+ cells reduced detectable beta cell expression of MafA, menin, and other factors that regulate beta cell function.
41	17259388	SHP downregulates insulin gene expression via two mechanisms: by downregulating PDX-1 and MafA gene expression and by inhibiting p300-mediated pancreatic duodenal homeobox factor 1-and BETA2-dependent transcriptional activity from the insulin promoter.
42	17449132	MafA is a recently isolated beta-cell-specific transcription factor which functions as a potent activator of insulin gene transcription.
43	17449132	Furthermore, MafA markedly enhances insulin gene promoter activity and ameliorates glucose tolerance in diabetic mice, especially in the presence of PDX-1 and NeuroD.
44	17627512	MafA is a recently isolated beta-cell-specific transcription factor which functions as a potent activator of insulin gene transcription.
45	17709883	The molecular mechanisms responsible for the glucose toxic effect on beta cell function involves disappearance of two important regulators of insulin promoter activity, PDX-1 and MafA.
46	17785922	MafA acts synergistically with Pdx1 and Beta2 to activate the insulin gene promoter, and mice with a targeted deletion of mafA develop age-dependent diabetes.
47	17785922	This review summarizes recent progress in determining the functions and roles of MafA in the regulation of insulin gene transcription in beta-cells.
48	17941991	Expression of either human insulin or the beta cell specific transcription factors PDX-1, NeuroD1 and MafA in the Hepa1-6 cell line or primary liver cells via adenoviral gene transfer, results in production and secretion of insulin.
49	17949261	Furthermore, TRX suppressed the reduction of Pdx-1 and MafA expression in the beta cells, which may be one of the cellular mechanisms for protecting beta cells from losing their insulin-secreting capacity.
50	17991758	Prolonged exposure of isolated islets of Langerhans to elevated levels of fatty acids, in the presence of high glucose, impairs insulin gene expression via a transcriptional mechanism involving nuclear exclusion of pancreas-duodenum homeobox-1 (Pdx-1) and loss of MafA expression.
51	18508668	MafA is a recently isolated beta-cell-specific transcription factor and functions as a potent activator of insulin gene transcription.
52	19393272	Recently, C1 element-binding transcription factor was identified as MafA, which is a basic-leucine zipper transcription factor and functions as a potent transactivator for the insulin gene.
53	19689288	MafA, PDX-1 and NeuroD directly bind to the insulin gene promoter and function as very important transcription factors in pancreatic beta-cell differentiation and mature beta-cell function.
54	20349222	Surprisingly, XBP1s overexpression impaired glucose-stimulated insulin secretion and increased beta cell apoptosis, whereas it protected fibroblasts against cell death induced by ER-stress. mRNA expression of Pdx1 and Mafa was inhibited in cells overproducing XBP1s, leading to decreased insulin expression.
55	21521872	Bcl-2, Cdk4, and c-myc expression levels were increased in Pax4 islets while MafA, insulin, and GLUT2 transcript levels were suppressed in both animal models.
56	21738894	The adenovirus-mediated overexpression of PDX-1, BETA2/NeuroD and MafA induced insulin gene expression in NPCCs, but not in adult pig pancreatic cells.
57	21395400	Forced expression (between days 16 and 25) of MafA, a pancreatic maturation factor, resulted in enhanced expression of insulin genes, glucose transporter 2 and glucokinase, and glucose-responsive insulin secretion.