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Gene Information

Gene symbol: LCAT

Gene name: lecithin-cholesterol acyltransferase

HGNC ID: 6522

Related Genes

#	Gene Symbol	Number of hits
1	CAT	1 hits
2	CETP	1 hits
3	INS	1 hits
4	LPL	1 hits
5	SCARB1	1 hits

Related Sentences

#	PMID	Sentence
1	2681900	Then HDL 2-cholesterol/HDL 3-cholesterol ratio was significantly increased from 4.8 to 5.1 (p less than 0.001) in insulin group. 4) LCAT activity were significantly decreased from 790 to 637 (nmol/ml.h) (p less than 0.05) in insulin group, but did not change in other two groups.
2	2681900	In conclusion, compared to diet alone and sulfonylurea groups, insulin group made significant reduction of HDL 3-cholesterol and LCAT activity during hospitalization.
3	7605366	There was no difference in the LPL activity, CETP and LCAT between diabetics and controls, whereas an increase in hepatic lipase activity was seen in the HTG diabetics (P < 0.05).
4	18437350	This study investigates whether the glycation inhibitors aminoguanidine and pyridoxamine, the insulin sensitiser metformin and the cross-link breaker alagebrium can inhibit and/or reverse the methylglyoxal-mediated glycation of ApoA-I and whether these changes can preserve or restore the ability of ApoA-I to activate LCAT.
5	18716026	It readily interacts with the ATP-binding cassette transporter ABCA1, the SR-B1 scavenger receptor; activates the enzyme lecithin-cholesterol acyl transferase (LCAT), which is critical for HDL maturation.
6	20521624	The decrease of lipids and apoprotein levels of VLDL and LDL were followed by stimulation of plasma post-heparin lipolytic activity and lecithin cholesterol acyltransferase as well as hepatic superoxide dismutase and catalase activities.
7	21252249	EST, LCAT activity, CET (P < 0.001 for all), and CETP (P = 0.030) were increased, and Lp-PLA(2) was decreased (P = 0.043) in MetS.