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Gene Information
Gene symbol: LGALS3
Gene name: lectin, galactoside-binding, soluble, 3
HGNC ID: 6563
Synonyms: MAC-2, GALIG
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IL1B | 1 hits |
| 2 | IL6 | 1 hits |
| 3 | MAPK8 | 1 hits |
| 4 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16600178 | Here analysis of human and rat islets and insulinoma cells confirmed IL-1beta regulated gal-3 expression of several gal-3 isoforms and a complex in vivo expression profile during diabetes development in rats. |
| 2 | 16600178 | Over-expression of gal-3 protected beta-cells against IL-1beta toxicity, with a complete blockage of JNK phosphorylation, essential for IL-1-mediated apoptosis. |
| 3 | 17641742 | Gal-3(-/-) mice showed significantly less diabetes-mediated iBRB dysfunction, junctional disruption, and VEGF expression changes than their WT counterparts. |
| 4 | 21189092 | Galectin-3 levels were correlated with higher IL-6 and CRP levels (P < 0.002). |