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Gene Information
Gene symbol: LIPA
Gene name: lipase A, lysosomal acid, cholesterol esterase
HGNC ID: 6617
Synonyms: LAL, CESD
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | LIPE | 1 hits |
| 3 | PPARG | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 6361450 | The effect of insulin treatment on the activity of lysosomal acid lipase requires further evaluation. |
| 2 | 12200416 | Because ACAT is the main enzyme responsible for cholesterol ester synthesis and HSL contributes significantly to neutral cholesterol ester hydrolase activity, this suggests that glucose primes the J774.2 cells so that in the presence of high insulin or leptin they will store cholesterol esters. |
| 3 | 21499898 | The LXR agonist T0901317 reversed the decreased LAL expression in modified LDL- or HODE-exposed EC (P < 0.001) and in gLDL-exposed SMC, whereas PPAR-gamma agonist rosiglitazone induced a low effect only in EC. |
| 4 | 21904679 | We tested the hypothesis that TAG accumulation in the liver induced by short-term high-fat diet (HFD) in rats leads to the dysregulation of endogenous TAG degradation by lysosomal lipase (LIPA) via lysosomal pathway and is causally linked with the onset of hepatic insulin resistance. |