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Gene Information
Gene symbol: LNPEP
Gene name: leucyl/cystinyl aminopeptidase
HGNC ID: 6656
Synonyms: CAP, PLAP, P-LAP
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AVP | 1 hits |
| 2 | GSTCD | 1 hits |
| 3 | INS | 1 hits |
| 4 | SLC2A4 | 1 hits |
| 5 | SYNGR2 | 1 hits |
| 6 | VAV1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 1992649 | These increases (MCR of AVP and plasma vasopressinase) may explain certain syndromes of transient diabetes insipidus (DI) that complicate gestation. |
| 2 | 8476482 | Transient diabetes insipidus of pregnancy (TDIP) is associated with elevated activity of vasopressinase, a plasma enzyme that opens the vasopressin (AVP) ring to produce a linear peptide that we have named vasopressinase-altered vasopressin (VAV). |
| 3 | 8476482 | AVP was incubated with vasopressinase and VAV was separated from residual AVP by high-pressure liquid chromatography. |
| 4 | 8334746 | Serum vasopressinase activity was measured during one of the pregnancies affected with diabetes insipidus and compared with that obtained between 26 and 38 weeks from 13 normal pregnancies. |
| 5 | 11981039 | The region of IRAP fused with glutathione-S-transferase [GST-IRAP(55-82)] was incubated with lysates from 3T3-L1 adipocytes, leading to identification of long-chain, medium-chain, and short-chain acyl-coenzyme A dehydrogenases (ACDs) as the proteins associated with IRAP. |
| 6 | 15231875 | Cardiac GLUT4 content is reduced by 65-85% in IRAP knockout mice, suggesting that IRAP may regulate the targeting or degradation of GLUT4. |
| 7 | 15231875 | In G4H-/- hearts, IRAP content was reduced by 60%, but the expression of other vesicle-associated proteins, namely cellugyrin, IGF-II/mannose-6-phosphate, and transferrin receptors, secretory carrier-associated membrane proteins and vesicle-associated membrane protein were unchanged. |
| 8 | 15231875 | Although insulin caused a discernible increase in cell surface IRAP content of G4H-/- cardiomyocytes, cell surface IRAP remained 70% lower than insulin-stimulated controls. |
| 9 | 15231875 | Immunoabsorption of intracellular vesicles with anticellugyrin antibodies revealed that IRAP content was reduced by 70% in both cellugyrin-positive and cellugyrin-negative vesicles. |
| 10 | 20953066 | Diabetes insipidus resulted from the increased activity of vasopressinase, caused by hemochromatosis-induced liver dysfunction, the presence of which was confirmed between the pregnancies by liver biopsy and identification of the HFE gene mutation. |