- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: LTF
Gene name: lactotransferrin
HGNC ID: 6720
Synonyms: HLF2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACACA | 1 hits |
| 2 | ADIPOQ | 1 hits |
| 3 | AKT1 | 1 hits |
| 4 | CAT | 1 hits |
| 5 | CCL2 | 1 hits |
| 6 | FABP4 | 1 hits |
| 7 | FASN | 1 hits |
| 8 | GSR | 1 hits |
| 9 | IL6 | 1 hits |
| 10 | INS | 1 hits |
| 11 | LPO | 1 hits |
| 12 | PRKAA2 | 1 hits |
| 13 | RB1 | 1 hits |
| 14 | STEAP4 | 1 hits |
| 15 | TFRC | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 2580790 | Insulin treatment had a significant effect on lysozyme and lactoperoxidase activity, recovering 73 and 74% those of the controls, respectively, and the ratio of lactoferrin to total salivary protein reverted to normal values. |
| 2 | 17216400 | Furthermore, even though human serum transferrin and lactoferrin are quite similar in sequence and structure, and coordinate iron in the same manner, they differ in their affinities for iron as well as their receptor binding properties: the human transferrin receptor only binds serum transferrin, and two distinct bacterial transport systems are used to capture iron from serum transferrin and lactoferrin. |
| 3 | 19584176 | Lactoferrin decreased nuclear factor-kappabeta activation and IL-6, IL-8, and macrophage chemoattractant protein-1 expression under LPS challenge. |
| 4 | 19696758 | In parallel to lipid changes, circulating lactoferrin concentrations were inversely linked to the variations in catalase (CAT) and glutathione reductase (GSH-Rd). |
| 5 | 21295959 | Lactoferrin has been associated with insulin sensitivity in vivo and in vitro studies. |
| 6 | 21295959 | The effects of lactoferrin on adipogenesis were studied through the expression of different adipogenic and inflammatory markers, AMPK activation and Retinoblastoma 1 (RB1) activity. |
| 7 | 21295959 | In both subcutaneous and visceral preadipocytes, lactoferrin (1 and 10 ?M) increased adipogenic gene expressions and protein levels (fatty acid synthase, PPAR?, FABP4, ADIPOQ, ACC and STAMP2) and decreased inflammatory markers (IL8, IL6 and MCP1) dose-dependently in parallel to increased insulin-induced (Ser473)AKT phosphorylation. |
| 8 | 21295959 | In addition to these adipogenic effects, lactoferrin decreased significantly AMPK activity (reducing (pThr172)AMPK and (pSer79)ACC) and RB1 activity (increasing the (pser807/811)RB1/RB1 ratio). |
| 9 | 21295959 | In conclusion, these results suggest that lactoferrin promotes adipogenesis in human adipocytes by enhancing insulin signaling and inhibiting RB1 and AMPK activities. |